{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:27:08Z","timestamp":1783013228359,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D deficiency is highly prevalent among children on regular dialysis, affecting approximately 90% of patients. This deficiency (serum 25\u2010hydroxyvitamin D\u2009&lt;\u200950 nmol\/L or 20\u2009ng\/mL) is associated with various complications, including skeletal problems, increased infection risk, arterial stiffness, vascular calcification, and higher cardiovascular mortality. Severe deficiency (&lt;\u200930\u2009nmol\/L) particularly increases mortality risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this cross\u2010sectional retrospective study, we examined 53 pediatric patients (28 boys, 25 girls) undergoing regular dialysis (hemodialysis and peritoneal dialysis) at a children's medical center from 2018 to 2020. The mean age was 8.21 years, with 71.7% aged 2\u201312 years, 20.8% adolescents, and 7.5% under 2 years. The mean vitamin D level was 23.51\u2009ng\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results showed that 26.41% of patients died, with mortality analysis revealing a hazard ratio of 3.2 for patients with vitamin D levels below 15\u2009ng\/mL. The mortality rate was 64.7% in severe deficiency (&lt;\u200915\u2009ng\/mL), 18.8% in moderate deficiency (15\u201330\u2009ng\/mL), while patients with sufficient levels (&gt;\u200930\u2009ng\/mL) recorded no deaths. Additionally, 11.32% developed skeletal disorders, including two cases of spinal fracture. Vitamin D levels showed significant positive correlations with calcium (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.6) and years under dialysis (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.52) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Associations were found between vitamin D levels and phosphorus, PTH, and mortality rates. However, no significant relationships were observed with dialysis frequency, age, weight, gender, underlying disease, dialysis type, or hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, children with end\u2010stage renal disease undergoing dialysis face increased risks of vitamin D deficiency due to impaired kidney function. This deficiency significantly impacts survival rates and contributes to poor outcomes. Regular monitoring and management of vitamin D levels are crucial for improving survival in pediatric dialysis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71804","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:07:22Z","timestamp":1770106042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Serum Vitamin D Levels and Mortality in Children Receiving Chronic Dialysis: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1247-8472","authenticated-orcid":false,"given":"Sima","family":"Shamshiri Khamene","sequence":"first","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0804-7511","authenticated-orcid":false,"given":"Izat Mohammad","family":"Khawajah","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-4504","authenticated-orcid":false,"given":"Mastaneh","family":"Moghtaderi","sequence":"additional","affiliation":[{"name":"Pediatric Chronic Kidney Disease Research Center, Gene, Cell &amp; Tissue Research Institute, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"issue":"7","key":"e_1_2_13_2_1","article-title":"Secondary Hyperparathyroidism in Chronic Kidney Disease: Pathophysiology and Management","volume":"13","author":"Habas E.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0312-5"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0038-9"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01414"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0264"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-018-1648-y"},{"key":"e_1_2_13_8_1","unstructured":"L.Hadjadj \u201cEffect of Hyperandrogenism and Vitamin D Deficiency on Metabolic Parameters and Coronary Artery Function in Female Rats\u201d (PhD diss.)."},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24451-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz037"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040328"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40795-023-00706-z"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-017-2413-2"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2016.11.010"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0558-y"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169135"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.265453"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-206"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24451-7"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3579-6"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.03.005"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx065"},{"issue":"3","key":"e_1_2_13_23_1","first-page":"220","article-title":"High Prevalence of Vitamin D Deficiency Among Children With Chronic Kidney Disease and Kidney Transplant","volume":"115","author":"Coccia P.","year":"2017","journal-title":"Archivos Argentinos de Pediatria"},{"issue":"2","key":"e_1_2_13_24_1","first-page":"267","article-title":"Assessment of Immune Status in Relation to Vitamin D Levels in Children on Regular Hemodialysis","volume":"23","author":"Youssef D. 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