{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:16:18Z","timestamp":1783016178713,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In many low\u2010income countries, gastroduodenal endoscopy under conscious sedation remains uncommon due to added costs and concerns about managing complications and side effects. This study aimed to assess the feasibility of performing the procedure without sedation, using a potent antinauseant as premedication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>We conducted a prospective, single\u2010center study between 2020 and 2022 in Bukavu, eastern Democratic Republic of the Congo. Endoscopies were performed without sedation, supplemented by a protocol involving sublingual ondansetron spray. Clinical outcomes, procedural data, and patient feedback before and after the procedure were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 145 patients were enrolled, including 76 men (52.4%). Only 12 patients (8.28%) reported poor tolerance. The majority (91.72%) tolerated the procedure well, especially those who followed instructions and for whom endoscope insertion was straightforward (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate analysis identified ease of endoscope insertion as the primary determinant of tolerance (adjusted OR 44.34 [2.78\u2013708.22],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Performing upper digestive endoscopy without sedation, but with ondansetron premedication, is generally well tolerated. Successful tolerance depends on thorough patient preparation and careful execution of the initial stages of the procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71853","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:46:58Z","timestamp":1771408018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ondasetron as Premedication for Unsedated Upper Digestive Endoscopy: A Cross\u2010Sectional Study Assessing Tolerance and Acceptability"],"prefix":"10.1002","volume":"9","author":[{"given":"Espoir Batumike","family":"Murhi","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of Congo"},{"name":"H\u00f4pital Provincial G\u00e9n\u00e9ral de R\u00e9f\u00e9rence de Bukavu (HPGRB) Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raissa Boroto","family":"Iranga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of Congo"},{"name":"Regional School of Public Health Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corneille","family":"Lembembu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of Congo"},{"name":"Regional School of Public Health Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-8088","authenticated-orcid":false,"given":"Tony Akilimali","family":"Shindano","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of Congo"},{"name":"H\u00f4pital Provincial G\u00e9n\u00e9ral de R\u00e9f\u00e9rence de Bukavu (HPGRB) Universit\u00e9 Catholique de Bukavu Bukavu South Kivu Democratic Republic of the Congo"},{"name":"CTDGH, Centre for Tropical Diseases and Global Health Catholic University of Bukavu Bukavu South Kivu Democratic Republic of the Congo"},{"name":"University of Kindu, Democratic Republic of the Congo Kindu Maniema Democratic Republic of the Congo"},{"name":"Faculty of Medicine Universit\u00e9 Officielle de Bukavu (UOB) Bukavu South Kivu Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_697_21"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199902000-00023"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.044"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.01112"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2015.56.6.1566"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1790-5996"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.123274"},{"key":"e_1_2_13_9_1","first-page":"1922","article-title":"Il Faut Relancer L'endoscopie Digestive En R\u00e9publique D\u00e9mocratique Du Congo It Is Necessary to Restart the Digestive Endoscopy in Democratic Republic of Congo","volume":"8","author":"Tshimpi A. W.","year":"2015","journal-title":"Janvier PTD, Ho\u00e9pato\u2010 R. Nasogastroscopie: l\u2019 \u00e2ge de raison?"},{"key":"e_1_2_13_10_1","volume-title":"Ondansetron","author":"Griddine A.","year":"2025"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.101160"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12157-015-0630-8"},{"key":"e_1_2_13_13_1","unstructured":"O.Salwa T.Mohamed M.Rachid B.Ahmed andB.Wafa. Acceptabilit\u00e9 de la fibroscopie \u0153sogastroduod\u00e9nale sans anesth\u00e9sie chez les patients marocains: \u00e9tude prospective [Acceptability of oeso\u2010gastro\u2010duodenal fibroscopy] accessed March 27 2023 https:\/\/www.snfge.org\/content\/acceptabilitede-la-fibroscopie-oeso-gastro-duodenale.pdf."},{"key":"e_1_2_13_14_1","first-page":"5","article-title":"Mbendi S. 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