{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:08Z","timestamp":1787250308738,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is a prevalent sleep disorder linked to cardiovascular diseases and is highly prevalent, especially in the elderly population. This study aimed to investigate the association between OSA severity and arterial stiffness, as measured by pulse wave velocity (PWV), in patients with moderate to severe OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 60 adults with moderate\u2010to\u2010severe OSA, confirmed by polysomnography (PSG). Arterial stiffness was measured by brachial artery oscillometry. Polysomnographic parameters, including the apnea\u2013hypopnea index (AHI), minimum oxygen saturation (SpO2), and sleep efficiency, were analyzed to determine their correlation with PWV. Correlations between PWV and PSG parameters were performed using Spearman's correlation coefficient. Additionally, multivariate regression analysis was conducted to adjust for confounders, including age, sex, BMI, hypertension, diabetes, and medication use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of participants was 62.07\u2009\u00b1\u20098.83 years, with 55% being male. A significant positive correlation was found between PWV and AHI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.4724; 95% CI\u2009=\u20090.2438 to 0.6512;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), indicating that arterial stiffness increases with OSA severity. Additionally, an inverse relationship was observed between PWV and minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u20100.2995; 95% CI\u2009=\u2009\u20130.5234 to \u20130.03684;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), as well as between PWV and sleep efficiency (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u20130.2702; 95% CI\u2009=\u2009\u22120.4999 to \u20130.004971;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). However, when adjusted for age and other potential confounders using multivariate regression, these associations between PSG parameters and arterial stiffness lost statistical significance. Age emerged as the primary independent predictor of PWV in this population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The study confirms a significant initial association between the severity of OSA, as indicated by AHI and minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      , and arterial stiffness. The subsequent analysis highlights that the relationship between sleep parameters and PWV is primarily age\u2010dependent, emphasizing the importance of rigorous cardiovascular risk assessment in aging OSA patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71861","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:32:38Z","timestamp":1773293558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between the Severity of Obstructive Sleep Apnea and Arterial Stiffness Estimated by Pulse Wave Velocity Assessment: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Erica","family":"Silva","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Giovana Teixeira","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Rodrigues Ferreira Gomes","family":"de Camargos","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia Mendon\u00e7a","family":"Nunes","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle Santos Pontello","family":"Neves","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia de Souza","family":"Pereira","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"},{"name":"Hospital da Pol\u00edcia Militar de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Felippe Pinho da","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-6685","authenticated-orcid":false,"given":"Daniel","family":"Mendes\u2010Pinto","sequence":"additional","affiliation":[{"name":"Hospital Fel\u00edcio Rocho Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-1707","authenticated-orcid":false,"given":"Maria da Gl\u00f3ria","family":"Rodrigues\u2010Machado","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-0572","authenticated-orcid":false,"given":"Bruno Almeida","family":"Rezende","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"e_1_2_14_3_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events","author":"Troester M. M.","year":"2023"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artere.2024.07.003"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000001065"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7967"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202111-2608OC"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30271-1"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-024-04344-6"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.11.48"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.17465"},{"issue":"2","key":"e_1_2_14_14_1","first-page":"242","article-title":"Cardiovascular Risk in Psoriasis Patients: Clinical, Functional and Morphological Parameters","volume":"113","author":"Oliveira A. N.","year":"2019","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.05.052"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2021\/e2350"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04238-1"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7616"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e328353ff63"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12156"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-211513"},{"issue":"5","key":"e_1_2_14_22_1","first-page":"667","article-title":"Sleep\u2010Related Breathing Disorders in Adults: Recommendations for Syndrome Definition and Measurement Techniques in Clinical Research","volume":"22","year":"1999","journal-title":"Report of an American Academy of Sleep Medicine Task Force. Sleep"},{"key":"e_1_2_14_23_1","volume-title":"Sleep Disorders in Hospitalized Adults: Evaluation and Management","author":"Auckley D.","year":"2018"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.36660\/abc.20201238"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S006"},{"key":"e_1_2_14_26_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Version 2.6","author":"American Academy of Sleep Medicine","year":"2020"},{"key":"e_1_2_14_27_1","first-page":"1","article-title":"Physical Status: The Use and Interpretation of Anthropometry. Report of a WHO Expert Committee","volume":"854","year":"1995","journal-title":"World Health Organization Technical Report Series"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3283614168"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.176313"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/31\/1\/R01"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13387"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000033"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14624"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-0490-5"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.037"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.762437"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-77932-4_10"},{"issue":"8","key":"e_1_2_14_38_1","first-page":"1071","article-title":"Sleep Disordered Breathing and Mortality: Eighteen\u2010Year Follow\u2010Up of the Wisconsin Sleep Cohort","volume":"31","author":"Young T.","year":"2008","journal-title":"Sleep"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-009-0298-7"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228905"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43648"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12384"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1438470"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2022.07.001"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232589"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0224-4"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.05.004"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886655"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128420.01881.aa"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.5578\/tt.20229708"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02346-0"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.71861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:44:50Z","timestamp":1787247890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/hsr2.71861"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71861","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71861"}}