{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:45Z","timestamp":1787250345145,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Local anesthetic systemic toxicity (LAST) is a rare but potentially life\u2010threatening complication associated with the use of local anesthetics. Prompt recognition and effective management are critical to preventing severe outcomes. However, studies have shown that healthcare workers' knowledge regarding LAST remains limited, especially in surgical settings where local anesthetics are frequently used. This study is to assess the current state and associated factors of knowledge regarding LAST among healthcare workers in the surgical departments of a hospital under the Ho Chi Minh City Department of Health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted from April 2024 to May 2025, involving 260 healthcare workers across 11 clinical departments. Data were collected using a structured, self\u2010administered questionnaire developed based on national guidelines for LAST diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nearly half of the participants (48.8%, 127\/260) reported having prescribed or administered local anesthetics. Among those with direct experience using local anesthetics, lidocaine was the most commonly used agent (88.2%, 112\/127). The majority of participants (81.9%, 213\/260) correctly recognized that local anesthetic systemic toxicity (LAST) may occur even when local anesthetics are administered within recommended dosage ranges. However, only 22.3% (58\/260) perceived themselves as knowledgeable about LAST. Regarding lipid emulsion therapy, 33.8% (88\/260) reported having heard of 20% lipid emulsion therapy, whereas 43.9% (114\/260) had never heard of this intervention. The most frequently identified early signs of LAST were tachycardia (64.6%, 168\/260) and hypertension (34.2%, 89\/260).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Healthcare workers in surgical departments demonstrated insufficient knowledge regarding local anesthetic toxicity, particularly in recognizing early symptoms and understanding the use of lipid emulsion therapy as a treatment strategy. Targeted training programs are warranted to enhance competency in LAST management and improve patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71946","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:41:45Z","timestamp":1773027705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Knowledge of Local Anesthetic Toxicity Among Healthcare Workers in Surgical Departments: A Hospital\u2010Based, Cross\u2010Sectional Study in Vietnam"],"prefix":"10.1002","volume":"9","author":[{"given":"Vu Tri","family":"Thanh","sequence":"first","affiliation":[{"name":"Thu Duc General Hospital Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Ngo Khai","family":"Vy","sequence":"additional","affiliation":[{"name":"Preventive Medicine Class of 2021, Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6783-6936","authenticated-orcid":false,"given":"Giap Thi Mai","family":"Linh","sequence":"additional","affiliation":[{"name":"Preventive Medicine Class of 2021, Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Hoai","family":"Huy","sequence":"additional","affiliation":[{"name":"Preventive Medicine Class of 2021, Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Diep Bao","family":"Liem","sequence":"additional","affiliation":[{"name":"Preventive Medicine Class of 2021, Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Huu Khanh","family":"Linh","sequence":"additional","affiliation":[{"name":"Preventive Medicine Class of 2021, Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-2822","authenticated-orcid":false,"given":"Vo Y","family":"Lan","sequence":"additional","affiliation":[{"name":"Kanagawa University of Human Services Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Kim","family":"Anh","sequence":"additional","affiliation":[{"name":"Thu Duc General Hospital Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-1644","authenticated-orcid":false,"given":"Ho Tat","family":"Bang","sequence":"additional","affiliation":[{"name":"University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"},{"name":"Department of Health Management, Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.38103\/jcmhch.87.14"},{"issue":"2","key":"e_1_2_11_3_1","article-title":"Successful Emergency Management of a Patient With Systemic Local Anesthetic Toxicity After Spinal Anesthesia: A Case Report","volume":"1","author":"Hung T. 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