{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:26:00Z","timestamp":1787250360287,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>To evaluate the transition of Carbohydrate antigen 125 (CA\u2010125) from an ovarian tumor marker to a versatile indicator of systemic congestion and fluid overload.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature review (1984\u20132025) was conducted using PubMed, Scopus, and Web of Science. Keywords included \u201cCA\u2010125,\u201d \u201csystemic congestion,\u201d and related terms. Studies on the diagnostic and prognostic value of CA\u2010125 in congestive disorders were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CA\u2010125 is synthesized by mesothelial cells in response to mechanical stress and inflammation, particularly via c\u2010Jun N\u2010terminal kinase (JNK) signaling pathways. It provides significant prognostic value in heart failure (HF), renal failure, and cirrhosis, often rivaling or complementing NT\u2010proBNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CA\u2010125 is a versatile biomarker for systemic congestion, offering diagnostic and prognostic value across cardiology, nephrology, and hepatology. Refining its clinical application could optimize fluid management in diverse patient populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71964","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:19:00Z","timestamp":1772972340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Tumor Marker to Congestion Indicator: The Expanding Role of CA\u2010125 in Heart Failure and Beyond"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8058-6467","authenticated-orcid":false,"given":"Minoo Heidari","family":"Almasi","sequence":"first","affiliation":[{"name":"Clinical Research Development Center, Imam Hossein Educational Hospital Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-3742","authenticated-orcid":false,"given":"Seyed Amirhossein","family":"Salehi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8569-2389","authenticated-orcid":false,"given":"Azin","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Scientific Researcher Razi Hospital, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-7226","authenticated-orcid":false,"given":"Ladan","family":"Heidaresfahani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tehran Medical Sciences, Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-0965","authenticated-orcid":false,"given":"Amirahmad","family":"Nassiri","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123730"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rccl.2023.01.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2017.00070"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2021.22"},{"issue":"8","key":"e_1_2_11_6_1","first-page":"14","article-title":"Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure","volume":"795","author":"Marinescu M. 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