{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:26:01Z","timestamp":1787250361093,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Systemic inflammation indices derived from complete blood counts (CBC) are accessible markers of inflammatory burden, but their relationship with circulating cytokines in psoriasis remains unclear. We investigated associations between CBC\u2010derived indices and serum cytokines in psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, we included 28 patients with psoriasis and 23 healthy controls. Serum IL\u201017, IL\u201022, IL\u201023, IL\u201031, IL\u201033, IL\u201036, TNF\u2010\u03b1, TGF\u2010\u03b2, and IFN\u03b3 were quantified by ELISA. CBC\u2010derived indices were computed (neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), systemic immune\u2010inflammation index (SII), systemic inflammation response index (SIRI), and pan\u2010immune\u2010inflammation value (PIV). Case\u2013control comparisons used the full sample. Cytokine\u2013index associations were evaluated in psoriasis patients using bivariate correlations and multivariate GLM adjusted for age, smoking, and NAFLD. Multiplicity was controlled using Benjamini\u2013Hochberg false discovery rate (BH\u2010FDR); prespecified sensitivity analyses used log\u2010transformed cytokines and Spearman correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Psoriasis patients had higher levels of all cytokines (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher SIRI versus controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>q<\/jats:italic>\n                      \u2009=\u20090.005). PIV showed a nominal case\u2013control difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) that did not remain significant after BH\u2010FDR (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009=\u20090.055), while NLR, PLR, and SII did not differ. In adjusted multivariate GLM, TGF\u2010\u03b2 showed a global association with the joint set of indices (Pillai's trace = 0.295;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) that did not survive BH\u2010FDR (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009=\u20090.507) and was attenuated with log\u2010transformation. Nominal univariate effects for TNF\u2010\u03b1 on SIRI (F\u2009=\u20094.600;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) and PIV (F\u2009=\u20095.660;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) did not remain significant after BH\u2010FDR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SIRI was consistently elevated in psoriasis, whereas PIV showed a nominal difference versus controls. Across exploratory analyses, SIRI and PIV showed the most consistent directional co\u2010variation with cytokines, but associations were modest. These findings are hypothesis\u2010generating and support further validation in larger cohorts to determine whether CBC\u2010derived indices can serve as scalable adjunct markers of inflammatory activity in psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71966","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:27:17Z","timestamp":1772972837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Inflammatory Cytokines and Systemic Inflammation Indices in Patients With Psoriasis: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7338-2300","authenticated-orcid":false,"given":"Luca","family":"Schneller\u2010Pavelescu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Marina Baixa Hospital Villajoyosa Alicante 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Medicine Miguel Hern\u00e1ndez University Alicante Spain"},{"name":"Department of Internal Medicine, Dr. Balmis General University Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Belinch\u00f3n\u2010Romero","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Miguel Hern\u00e1ndez University Alicante Spain"},{"name":"Department of Dermatology, Dr. Balmis General University Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante 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