{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:31:01Z","timestamp":1787610661052,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The introduction of radiation in medicine has led to significant breakthroughs in diagnostic, interventional, and therapeutic practices. However, the increasing demand for medical radiation has also raised concerns regarding cumulative exposure among both patients and healthcare workers, potentially leading to serious long\u2010term complications, including cancer. This article presents perspectives on the radioprotective potential of ascorbic acid (vitamin C) and discusses its possible role in mitigating the effects of ionizing radiation among at\u2010risk populations, including patients and healthcare workers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant literature addressing the short\u2010 and long\u2010term consequences of exposure to ionizing radiation, as well as studies exploring the radioprotective potential of ascorbic acid, was reviewed. Articles aligned with the main objective were synthesized to inform the perspectives presented in this paper.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Several strategies are currently employed to ensure radiation safety for both patients and healthcare workers. However, even when these measures are properly implemented, they do not guarantee complete protection from radiation exposure. Ascorbic acid (vitamin C), a potent antioxidant, has been widely studied for its therapeutic properties, and existing literature suggests that it may play a significant role in protecting against and reducing the harmful effects of ionizing radiation in susceptible individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Recommendations<\/jats:title>\n                    <jats:p>Vitamin C is a potent antioxidant with demonstrated radioprotective properties that may help reduce the harmful effects of ionizing radiation. Routine supplementation or increased dietary intake of vitamin C may benefit patients and healthcare workers at elevated risk of radiation exposure. However, further clinical trials are needed to determine its prophylactic efficacy, optimal dosage, and intake frequency before it can be incorporated as a standard radioprotective strategy in clinical and other high\u2010exposure settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71996","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:09:58Z","timestamp":1773979798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radioprotective Effect of Ascorbic Acid: A Need for Prophylactic Supplementation Pre\u2010 and Post\u2010Radiation Exposure Among Patients and Healthcare Workers\u2014A Perspective Article"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9811-9717","authenticated-orcid":false,"given":"Justice","family":"Mushemba","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, KCMC University Moshi Tanzania"},{"name":"Department of General Surgery School of Medicine, KCMC University Moshi Tanzania"},{"name":"Department of Internal Medicine School of Medicine, KCMC University Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8895-4639","authenticated-orcid":false,"given":"Cornel M.","family":"Angolile","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, KCMC University Moshi Tanzania"},{"name":"Department of Clinical Physiology School of Medicine, KCMC University Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaynes F.","family":"Kabuhaya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, KCMC University Moshi Tanzania"},{"name":"Department of General Surgery School of Medicine, KCMC University Moshi Tanzania"},{"name":"Department of Internal Medicine School of Medicine, KCMC University Moshi Tanzania"},{"name":"Department of Radiology School of Medicine, KCMC University Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-234X","authenticated-orcid":false,"given":"Harold L.","family":"Mashauri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, KCMC University Moshi Tanzania"},{"name":"Department of Internal Medicine School of Medicine, KCMC University Moshi Tanzania"},{"name":"Department of Clinical Physiology School of Medicine, KCMC University Moshi Tanzania"},{"name":"Department of Radiology School of Medicine, KCMC University Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JVS.2010.07.024"},{"key":"e_1_2_12_3_1","unstructured":"World Health Organization \u201cRadiological Health \u2010 PAHO\/WHO \u201d Pan American Health Organization."},{"key":"e_1_2_12_4_1","unstructured":"World Health Organization \u201cIonizing Radiation Health Effects and Protective Measures \u201d World Health Organization."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5164970"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/IJMS.3635"},{"key":"e_1_2_12_7_1","unstructured":"N.FraneandA.Bitterman Radiation Safety and Protection(StatPearls 2022)."},{"key":"e_1_2_12_8_1","unstructured":"S.AkramandY. 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