{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:02:25Z","timestamp":1789984945548,"version":"4.0.1"},"reference-count":121,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Breast cancer represents the most prevalent malignant neoplasm and remains a principal cause of mortality among women worldwide. Despite extensive investigation, the association between dietary fat intake and breast cancer risk has yet to be definitively established. Consequently, this study aimed to conduct a systematic review and meta\u2010analysis of existing case\u2010control and cohort studies to elucidate the relationship between overall dietary fat consumption and breast cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search was conducted across online databases up to May 2025 to identify relevant case\u2010control and cohort studies. The meta\u2010analysis employed a random\u2010effects model to pool multivariable\u2010adjusted effect sizes (ESs), evaluating heterogeneity using the\n                      <jats:italic>I<\/jats:italic>\n                      \u00b2 statistic and assessing publication bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The meta\u2010analysis of 75 ESs from case\u2010control studies indicated that women with the highest total dietary fat intake had a significantly increased risk of breast cancer compared to those with the lowest intake (ES: 1.23; 95% CI: [1.12, 1.34];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      \u00b2\u2009=\u200967%), suggesting a 23% higher risk. In contrast, the pooled analysis of 59 ESs from cohort studies showed no statistically significant association between total dietary fat intake and breast cancer risk (ES: 1.03; 95% CI: [0.99, 1.06];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.112;\n                      <jats:italic>I<\/jats:italic>\n                      \u00b2\u2009=\u200945%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Case\u2010control studies demonstrate a significant association between total dietary fat intake and breast cancer risk, whereas cohort studies do not report a statistically significant relationship. This disparity suggests a possible short\u2010term effect of dietary fat on breast cancer risk, while evidence regarding its long\u2010term impact remains inconclusive and warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72017","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:16:49Z","timestamp":1782213409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Dietary Total Fat Intake and Risk of Breast Cancer: A Meta\u2010Analysis of Case\u2010Control and Cohort Studies"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4388-0214","authenticated-orcid":false,"given":"Mehdi","family":"Karimi","sequence":"first","affiliation":[{"name":"Faculty of Medicine Bogomolets National Medical University (NMU) Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8234-4799","authenticated-orcid":false,"given":"Malihe","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Health Human Performance and Recreation Sport and Exercise Science University of Arkansas Fayetteville Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2627-6848","authenticated-orcid":false,"given":"Eshagh","family":"Sedighi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Islamic Azad University Branch of Urmia Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-9075","authenticated-orcid":false,"given":"Maryam","family":"Sharifi","sequence":"additional","affiliation":[{"name":"School of Nutritional Sciences and Food Technology Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0777-7646","authenticated-orcid":false,"given":"Kimia","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Islamic Azad University Ayatollah Amoli Branch Amol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-4711","authenticated-orcid":false,"given":"Omid","family":"Asbaghi","sequence":"additional","affiliation":[{"name":"Cancer Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2657-y"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.08.010"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2022.08.004"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16162644"},{"key":"e_1_2_14_6_1","doi-asserted-by":"crossref","unstructured":"Y.Song J.Li M.Zhu et al. 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