{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:30Z","timestamp":1786977810048,"version":"build-2736575974"},"reference-count":139,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is primarily known for its motor symptoms but is increasingly recognized for its substantial cognitive effects, particularly on memory. This narrative review aims to clarify the complex molecular mechanisms contributing to memory impairment in PD by integrating findings from both animal and clinical research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a narrative review synthesizing data from existing literature. It begins by addressing the prevalence of cognitive deficits among PD patients. It then explores animal studies investigating pathophysiological changes associated with PD, focusing on the impact of dopaminergic depletion on neural circuitry. These findings are integrated with clinical research to identify specific molecular changes closely associated with memory impairment independent of motor dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The review systematically examines key molecular mechanisms contributing to memory deficits in PD. These mechanisms include disruptions in neural circuits, dopamine depletion, neuroinflammation, oxidative stress, and alpha\u2010synuclein pathology. Additional contributing factors identified include cholinergic system dysfunction, cortical thinning and atrophy, disrupted neural oscillations, gut\u2010brain axis dysfunction, impaired synaptic plasticity, and alterations in neurotransmitter systems. The analysis illustrates how these factors collectively undermine cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>By synthesizing insights from various studies, this narrative review offers a comprehensive perspective on the intricate molecular pathogenesis of memory impairment in PD. It underscores the necessity of addressing both motor and non\u2010motor symptoms in managing PD effectively and advocates for a holistic treatment approach that considers cognitive decline alongside traditional motor symptom management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72024","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:49:34Z","timestamp":1776833374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular Pathogenesis of Memory Impairment in Parkinson's Disease: An Exploration of Underlying Mechanisms"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0510-3194","authenticated-orcid":false,"given":"Mohammad","family":"Pourfridoni","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center Shahid Sadoughi University of Medical Sciences Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Hakemi","sequence":"additional","affiliation":[{"name":"Student Research Committee Jiroft University of Medical Sciences Jiroft Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-5603","authenticated-orcid":false,"given":"Habibeh","family":"Mashayekhi\u2010sardoo","sequence":"additional","affiliation":[{"name":"Student Research Committee Jiroft University of Medical Sciences Jiroft Iran"},{"name":"Bio Environmental Health Hazards Research Center Jiroft University of Medical Sciences Jiroft Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-2558","authenticated-orcid":false,"given":"Yousef","family":"Baghcheghi","sequence":"additional","affiliation":[{"name":"Student Research Committee Jiroft University of Medical Sciences Jiroft Iran"},{"name":"Bio Environmental Health Hazards Research Center Jiroft University of Medical Sciences Jiroft Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.18863\/pgy.1374234"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00280-3"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00963-x"},{"key":"e_1_2_13_5_1","first-page":"1","article-title":"A Comprehensive Review of Natural Compounds and Their Structure\u2013Activity Relationship in Parkinson's Disease: Exploring Potential Mechanisms","volume":"398","author":"Merghany R. 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