{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:19Z","timestamp":1787250319333,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K09331"],"award-info":[{"award-number":["JP22K09331"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Psoriasis is a skin disorder complicated by arthritis and enthesitis. The cytokines interleukin (IL)\u201017, IL\u201023, and tumor necrosis factor (TNF)\u2010\u03b1 are reportedly key effectors of psoriasis. Additionally, gamma delta (\u03b3\u03b4) T cells exacerbate inflammation by producing inflammatory cytokines such as IL\u201017 and TNF\u2010\u03b1. However, details regarding the mechanisms linking pathogenesis and mechanical stress remain unclear. This study aimed to investigate the effect of strenuous exercise on the pathology of psoriasis using mouse models of imiquimod (IMQ)\u2010induced psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty mice were randomly assigned to four groups: IMQ\u2009\u2212\u2009TRED\u2212 (control), IMQ\u2009\u2212\u2009TRED+ (treadmill running mice), IMQ\u2009+\u2009TRED\u2212 group (IMQ treated mice), and IMQ\u2009+\u2009TRED+ group (IMQ treated and treadmill running mice). The tissue sections from back skin and thymus were immunostained with antibodies against IL\u201017, IL\u201023, and \u03b3\u03b4 T cells. Shoulder sections were stained using hematoxylin and eosin, and Toluidine Blue and Picrosirius Red. Additionally, the shoulder tissue sections were immunostained with antibodies against TNF\u2010\u03b1 and matrix metalloproteinase (MMP)\u201013. Serum cytokine level was measured to evaluate systemic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Strenuous exercise exacerbated pathological changes associated with psoriasis, including increased \u03b3\u03b4 T cell infiltration and upregulated IL\u201017 and IL\u201023 expression in the skin, as well as enhanced \u03b3\u03b4 T cell development and IL\u201017 expression in the thymus. Although strenuous exercise did not further worsen the modified PASI scores, histological and immunological markers of inflammation were significantly enhanced. Serum levels of TNF\u2010\u03b1 and IL\u201017 were significantly elevated in IMQ\u2010induced psoriasis model mice. Moreover, pathological changes induced by strenuous exercise were observed in the enthesis, including angiogenesis and upregulated expression of TNF\u2010\u03b1 and MMP\u201013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed that strenuous exercise exacerbates pathological changes in IMQ\u2010induced psoriasis model mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72040","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:47:17Z","timestamp":1773204437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Overload on Imiquimod\u2010Induced Psoriasis Model Mice: A Basic Experimental 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