{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:41:01Z","timestamp":1789688461518,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008323","name":"Zanjan University of Medical Sciences","doi-asserted-by":"publisher","award":["A\u201011\u20101527\u20106"],"award-info":[{"award-number":["A\u201011\u20101527\u20106"]}],"id":[{"id":"10.13039\/501100008323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Obsessive\u2013compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology. Dextromethorphan (DXM), an N\u2010methyl\u2010\n                      <jats:sc>d<\/jats:sc>\n                      \u2010aspartate (NMDA) receptor antagonist with additional monoaminergic and sigma\u20101 receptor activity, may modulate this system. This study evaluated the safety and efficacy of DXM augmentation in adults with moderate to severe OCD receiving stable SSRI treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, double\u2010blind, placebo\u2010controlled pilot trial 40 adults with moderate to severe OCD (Y\u2010BOCS\u2009&gt;\u200916) and inadequate response to at least 12 weeks of adequate\u2010dose SSRI monotherapy were assigned to DXM (15\u2009mg twice daily) or matched placebo, in addition to their ongoing SSRI, for 12 weeks. OCD symptom severity was assessed using the Yale\u2013Brown Obsessive Compulsive Scale (Y\u2010BOCS) at baseline, week 4, and week 12. Repeated\u2010measures analysis of variance (ANOVA) was used to examine changes over time. The primary outcome was the time\u2009\u00d7\u2009group interaction in Y\u2010BOCS. Secondary outcomes were not assessed. Trial registration: IRCT20221227056943N1; Ethics approval: IR.ZUMS.REC.1401.236.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline demographic and clinical characteristics were similar between groups. The DXM group showed a significant reduction in Y\u2010BOCS scores from 26.55\u2009\u00b1\u20096.19 at baseline to 16.30\u2009\u00b1\u20096.94 at week 12, whereas the placebo group remained relatively unchanged. Repeated\u2010measures ANOVA revealed a significant group\u2009\u00d7\u2009time interaction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      \u00b2\u2009=\u20090.662) and significant main effects of both group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) and time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). DXM was well tolerated with no side effects. No secondary outcomes were measured in this pilot study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dextromethorphan augmentation significantly reduced OCD symptom severity in patients with partial response to SSRIs, supporting its potential role as an adjunctive treatment. These findings warrant larger, longer\u2010term trials to confirm efficacy, determine optimal dosing, and clarify neurobiological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72055","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:29:21Z","timestamp":1778045361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Dextromethorphan Augmentation in SSRI\u2010Resistant Obsessive\u2013Compulsive Disorder: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Ahmad","family":"Zolghadriha","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Shahid Beheshti Hospital Zanjan University of Medical Sciences Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afagh","family":"Anjomshoaa","sequence":"additional","affiliation":[{"name":"Zanjan Metabolic Diseases Research Center Zanjan University of Medical Sciences Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9115-3404","authenticated-orcid":false,"given":"Romina","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shahid Beheshti Hospital Zanjan University of Medical Sciences Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"issue":"5","key":"e_1_2_13_2_1","article-title":"Management and Treatment of Obsessive\u2013Compulsive Disorder (OCD): A Literature Review","volume":"16","author":"Elsouri K. 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