{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:07Z","timestamp":1787250307375,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n To investigate the effects of a 6\u2010month supervised, personalized combined aerobic and resistance training program on oxidative stress, antioxidant capacity, infection\u2010related biomarkers, and body composition in maintenance hemodialysis (MHD) patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this single\u2010center, randomized controlled trial (nonblinded, parallel design), 61 MHD patients (standard thrice\u2010weekly 4\u2010h sessions) were randomly assigned to either an exercise group (\n n<\/jats:italic>\n \u2009=\u200936) or a control group (\n n<\/jats:italic>\n \u2009=\u200935). The exercise intervention comprised: The exercise group received 6 months of supervised training (three times a week, 2\u2009h before dialysis), including: \u2460Aerobic exercise: A 20\u2010min stationary cycling session at RPE 13 (with heart rate maintained at 60%\u201370% of maximum heart rate). \u2461Resistance training: Four lower\u2010body exercises (leg extension, straight leg raise, hip abduction, hip flexion) using ethylene\u2010vinyl acetate resistance bands (10\u2009reps\/set, RPE 13). The control group received standard care. Primary outcomes were oxidative stress markers (MDA, AOPP), antioxidant indicators (CAT, THIOL, TBIL), infection markers (IL\u20116, PCT, CRP, Hcy), and body composition measures (muscle mass, BMI).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After 6 months of intervention, the exercise group exhibited significantly reduced levels of MDA (\n p<\/jats:italic>\n \u2009<\u20090.05) and AOPP (\n p<\/jats:italic>\n \u2009<\u20090.05). CAT activity (\n p<\/jats:italic>\n \u2009<\u20090.05), THIOL levels (\n p<\/jats:italic>\n \u2009<\u20090.05), and TBIL levels (\n p<\/jats:italic>\n \u2009<\u20090.001) were significantly increased. IL\u20106, PCT, CRP, and Hcy were lower than those in the control group (\n p<\/jats:italic>\n \u2009<\u20090.05). The exercise group also demonstrated improved Kt\/V (\n p<\/jats:italic>\n \u2009<\u20090.05) and attenuated declines in muscle mass and BMI compared to controls (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This structured exercise program effectively mitigates oxidative damage, boosts antioxidant defenses, reduces infection markers, and enhances dialysis efficiency and body composition in MHD patients. These findings provide evidence for incorporating supervised exercise as a novel therapeutic strategy in nephrology care.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hsr2.72058","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:19:52Z","timestamp":1773116392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Influence of Aerobic and Strength Training on Oxidative Stress and Antioxidant Status in Hemodialysis Patients: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Yuwei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shenzhen People's Hospital, The Second Clinical Medical College Jinan University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen People's Hospital, The Second Clinical Medical College Jinan University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen People's Hospital, The Second Clinical Medical College Jinan University Shenzhen China"},{"name":"Department of Nephrology, Shenzhen Key Laboratory of Renal, Shenzhen People's Hospital (The Second Clinical Medical College Jinan University; The First Affiliated Hospital, Southern University of Science and Technology) Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Key Laboratory of Renal, Shenzhen People's Hospital (The Second Clinical Medical College Jinan University; The First Affiliated Hospital, Southern University of Science and Technology) Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Key Laboratory of Renal, Shenzhen People's Hospital (The Second Clinical Medical College Jinan University; The First Affiliated Hospital, Southern University of Science and Technology) Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-2298","authenticated-orcid":false,"given":"Liping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen People's Hospital, The Second Clinical Medical College Jinan University Shenzhen China"},{"name":"Department of Nephrology, Shenzhen Key Laboratory of Renal, Shenzhen People's Hospital (The Second Clinical Medical College Jinan University; The First Affiliated Hospital, Southern University of Science and Technology) Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jorc.12380"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2021.11.003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0646-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.230"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-021-02037-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-022-03146-z"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102364"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-226"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257918"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2492365"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1484662"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11010103"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2015.02.004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504955"},{"issue":"1","key":"e_1_2_12_16_1","first-page":"232","article-title":"Effects of Home\u2010Based Exercise Training on Cardiac Autonomic Neuropathy and Metabolic Profile in Diabetic Hemodialysis Patients","volume":"13","author":"Michou V.","year":"2023","journal-title":"Life (Basel, Switzerland)"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac046"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092600"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006121329"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.73442"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:44:31Z","timestamp":1787247871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/hsr2.72058"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72058","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72058"}}