{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:23Z","timestamp":1787250323068,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Bangladesh has dramatically reduced its malaria burden since 2000, confining the disease to specific geographic zones. However, the national 2030 elimination goal is now threatened by a complex interplay of biological, ecological, and social factors. This narrative review synthesizes the country's malaria landscape from 2000 to 2025, analyzes the headwinds to elimination, and proposes a strategic framework that integrates genomic surveillance to address the nuanced challenges of residual transmission for the \u201clast\u2010mile\u201d effort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review of scientific literature (January 2000\u2013June 2025) was conducted using PubMed and Medline. The search strategy utilized relevant Medical Subject Headings (MeSH) to identify English\u2010language, peer\u2010reviewed articles on Bangladeshi malaria epidemiology, diagnostics, treatment, vector biology, and health systems, focusing on health outcomes and prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The review confirms a\u2009&gt;\u200990% reduction in malaria cases (2008\u20132020) driven by targeted vector control, RDTs, and ACTs, concentrating the remaining burden in the Chittagong Hill Tracts (CHT). While\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      remains the dominant species responsible for the majority of the clinical burden, emerging challenges include: (1) biological threats like non\u2010\n                      <jats:italic>kelch13<\/jats:italic>\n                      artemisinin\u2010partial resistance in\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      and complexities of\n                      <jats:italic>Plasmodium vivax<\/jats:italic>\n                      radical cure amid G6PD deficiency; (2) ecological factors such as outdoor\u2010biting vectors that evade bed nets; and (3) social dynamics, including high cross\u2010border mobility and a large asymptomatic infection reservoir.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The 2030 elimination target is attainable but requires a strategic pivot from broad control to a granular, intelligence\u2010driven approach. Success depends on implementing solutions for outdoor\u2010biting vectors, mainstreaming routine G6PD screening for safe\n                      <jats:italic>P. vivax<\/jats:italic>\n                      cure, and deploying robust genomic epidemiological surveillance to detect parasite resistance and human mobility. Addressing the specific needs of forest\u2010going and ethnic minority communities bearing the remaining risk is essential for stopping the final transmission.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72077","type":"journal-article","created":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T13:30:24Z","timestamp":1773581424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Malaria in Bangladesh, 2000\u20132025: Navigating the Headwinds From Control to Elimination"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7548-2747","authenticated-orcid":false,"given":"Abdullaha Al","family":"Mamun","sequence":"first","affiliation":[{"name":"Chittagong Medical College Chattogram Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Sarwar A.","family":"Kayenat","sequence":"additional","affiliation":[{"name":"Chittagong Medical College Chattogram Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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