{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:59Z","timestamp":1787250359098,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mpox is a zoonotic viral disease caused by the monkeypox virus, with potential for significant morbidity across all population groups, including pregnant individuals and neonates. Pregnancy represents an immunologically vulnerable state, rendering affected mothers more susceptible to severe disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide obstetricians and maternal\u2010fetal medicine specialists with an updated synthesis of the clinical presentation, adverse outcomes, and evidence\u2010based management strategies for Mpox infection during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted across multiple electronic databases\u2010Web of Science, PubMed, Scopus, ScienceDirect, ProQuest, Cochrane Library, SAGE, Springer, and Google Scholar\u2010for peer\u2010reviewed studies addressing Mpox infection in pregnancy. Additionally, international guidelines and consensus statements were reviewed, including those from the World Health Organization (WHO), Royal College of Obstetricians and Gynecologists (RCOG), Centers for Disease Control and Prevention (CDC), Society for Maternal\u2010Fetal Medicine (SMFM), and American College of Obstetricians and Gynecologists (ACOG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mpox infection during pregnancy is associated with a spectrum of adverse maternal and perinatal outcomes. Pregnant individuals are at increased risk for disease exacerbation, necessitating hospitalization and intensive care. Documented perinatal complications include spontaneous miscarriage, preterm prelabour rupture of membranes (PPROM), preterm birth, intrauterine fetal demise, congenital Mpox infection, low birth weight, and neurodevelopmental delays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pregnant individuals diagnosed with Mpox should be prioritized for hospital admission, isolation, antiviral therapy, and continuous monitoring of maternal and fetal well\u2010being. Multidisciplinary coordination is essential to mitigate risks and optimize outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72111","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T06:01:47Z","timestamp":1773727307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mpox (Monkeypox) in Pregnancy Updates"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7324-3028","authenticated-orcid":false,"given":"Yeshey","family":"Dorjey","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Eastern Regional Referral Hospital Mongar Bhutan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1383-4436","authenticated-orcid":false,"given":"Deep Kiran","family":"Chhetri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Trashigang Hospital Trashigang Bhutan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268823000791"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1959.tb00328.x"},{"key":"e_1_2_7_4_1","unstructured":"WHO Director\u2010General declares mpox outbreak a public health emergency of international concern [Internet] https:\/\/www.who.int\/news\/item\/14-08-2024-who-director-general-declares-mpox-outbreak-a-public-health-emergency-of-international-concern."},{"key":"e_1_2_7_5_1","volume-title":"2022\u201024 Mpox (Monkeypox) Outbreak: Global Trends","author":"WHO","year":"2024"},{"key":"e_1_2_7_6_1","volume-title":"WHO Fact Sheets on Mpox","author":"WHO","year":"2024"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00034-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix260"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106832"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2410045"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.11.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00198-5"},{"key":"e_1_2_7_13_1","unstructured":"World Health Organisation Weekly epidemiological record Relev\u00e9 \u00e9pid\u00e9miologique hebdomadaire 2024;(34):429\u2013456."},{"key":"e_1_2_7_14_1","unstructured":"RCOG. Mpox (Monkeypox) in Pregnancy [Internet]. Royal Colleges of Obstetricians & Gynaecologists.2023 https:\/\/www.rcog.org.uk\/media\/mrpktraf\/2023-11-mpox-monkeypox-in-pregnancy.pdf."},{"key":"e_1_2_7_15_1","unstructured":"Clinical Overview of Mpox | Mpox | CDC [Internet] https:\/\/www.cdc.gov\/mpox\/hcp\/clinical-overview\/index.html."},{"issue":"8","key":"e_1_2_7_16_1","article-title":"Epidemiology, Clinical Features, Diagnosis and Management of Monkeypox Virus: A Clinical Review Article","volume":"14","author":"Ghazanfar A.","year":"2022","journal-title":"Cureus [Internet]"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa143"},{"key":"e_1_2_7_18_1","unstructured":"Mpox [Internet] https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mpox."},{"key":"e_1_2_7_19_1","unstructured":"Obstetric Care Considerations for Mpox | ACOG [Internet] https:\/\/www.acog.org\/clinical-information\/physician-faqs\/obstetric-care-considerations-mpox."},{"key":"e_1_2_7_20_1","unstructured":"Obstetric Care Considerations for Mpox | ACOG [Internet] https:\/\/www.acog.org\/clinical-information\/physician-faqs\/obstetric-care-considerations-mpox."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01063-7"},{"key":"e_1_2_7_22_1","volume-title":"BMJ Best Practice, Mpox Management Approach","author":"BMJ","year":"2024"},{"key":"e_1_2_7_23_1","unstructured":"National Institutes of Health. STOMP study of Tecovirimat for Mpox [Internet] 2024 https:\/\/www.stomptpoxx.org\/main."},{"key":"e_1_2_7_24_1","unstructured":"CDC Expanded Access IND Protocol: Use of Vaccinia Immune Globulin Intravenous (VIGIV CNJ\u2010016) for Treatment of Human Orthopoxvirus Infection in Adults and Children 2023."},{"key":"e_1_2_7_25_1","unstructured":"ACOG Obstetric Care Considerations for Mpox* [Internet] 2024 https:\/\/www.acog.org\/clinical-information\/physician-faqs\/obstetric-care-considerations-mpox."},{"key":"e_1_2_7_26_1","volume-title":"Mpox and Pregnancy: What Maternal Fetal Medicine Subspecialists Need to Know [Internet]","author":"SMFM","year":"2022"},{"key":"e_1_2_7_27_1","unstructured":"MVA\u2010BN (\u200eModified Vaccinia Ankara \u2013 Bavarian Nordic)\u200e Smallpox and Mpox Vaccine: Interim Guidance 27 November2024[Internet] https:\/\/www.who.int\/publications\/i\/item\/B09202."},{"key":"e_1_2_7_28_1","unstructured":"Mpox Clinical Care and Treatment During Pregnancy | Mpox | CDC [Internet] https:\/\/www.cdc.gov\/mpox\/hcp\/clinical-care\/pregnancy.html."},{"key":"e_1_2_7_29_1","unstructured":"CDC 2023. Clinical Considerations for Mpox in People Who are Pregnant or Breastfeeding https:\/\/www.cdc.gov\/poxvirus\/mpox\/clinicians\/pregnancy.html#:~:text=Infection%20control%20practices%20for%20the correct%20adherence%20to%20infection%20control."},{"key":"e_1_2_7_30_1","unstructured":"Public advice on mpox vaccination [Internet] https:\/\/www.who.int\/news-room\/public-advice\/mpox-vaccination."},{"key":"e_1_2_7_31_1","article-title":"Effectiveness of Modified Vaccinia Ankara\u2010Bavarian Nordic Vaccine Against Mpox Infection: Emulation of a Target Trial","volume":"386","author":"Navarro C.","year":"2024","journal-title":"BMJ [Internet]"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac622"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-026-01657-7"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:52:29Z","timestamp":1787248349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/hsr2.72111"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72111","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72111"}}