{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:18:27Z","timestamp":1788344307754,"version":"build-2803163510"},"reference-count":76,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006396","name":"Qazvin University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Breast cancer is the most common cancer among women worldwide. This study aimed to determine the frequency of breast cancer molecular subtypes and the associations of ER, PR, and HER2 status with demographic, reproductive, hormonal, and cancer stage in Qazvin, Iran (2021\u20132023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross\u2010sectional study, 333 women with primary breast cancer were evaluated. Demographic, reproductive, hormonal, and cancer stage data were extracted from medical records and interviews. ER, PR, HER2, and Ki67 were assessed by immunohistochemistry. Group comparisons were performed using\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      and\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, and multinomial logistic regression was used to determine associations with tumor stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The mean age at diagnosis was 50 years. Eighty\u2010two percent of the patients had a history of breastfeeding, and 20.9% reported a family history of breast cancer. The most common molecular subtype was luminal A (47%), followed by luminal B (HER2+: 15%, HER2\u2212: 6%), HER2\u2010enriched (16%), and triple\u2010negative breast cancer (14%). The ER, PR, and HER2 positivity rates were 68.5%, 62.5%, and 32.7%, respectively. ER\u2212 and PR\u2212 tumors were more frequently diagnosed at advanced stages (stage III: ER\u2212 31.3% vs. ER+ 14.5%; PR\u2212 31.9% vs. PR+ 12.5%). HER2+ tumors were significantly associated with the absence of family history (8.3% vs. 28.2% in HER2\u2212) and higher stage at diagnosis (stage III: 26.0% vs. 16.5%). HER2\u2010positive tumors had significantly higher odds of presenting at stage II (OR\u2009=\u20091.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and stage III (OR\u2009=\u20092.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) compared with stage I, whereas PR\u2010positive tumors were significantly less likely to present at stage III (OR\u2009=\u20090.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Luminal A was the predominant subtype. Hormone receptor and HER2 status correlated with advanced stage, and HER2+ tumors were more frequent in patients without a family history. These results emphasize the importance of molecular profiling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72150","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:37:20Z","timestamp":1778737040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Breast Cancer Molecular Subtypes and Receptor\u2010Related Risk Factor Associations: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-1466","authenticated-orcid":false,"given":"Ensiyeh","family":"Bahadoran","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center, Research, Institute for Prevention of Non\u2010Communicable Diseases Qazvin University of Medical Sciences Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Mirzahosseini","sequence":"additional","affiliation":[{"name":"School of Medicine Qazvin University of Medical Sciences Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-2395","authenticated-orcid":false,"given":"Monir","family":"Mirzadeh","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Research Center, Research Institute for Prevention of Non\u2010Communicable Diseases Qazvin University of Medical Sciences Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-7902","authenticated-orcid":false,"given":"Yazdan","family":"Zafari","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, School of Medicine Qazvin University of Medical Sciences Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7653-8689","authenticated-orcid":false,"given":"Sahar","family":"Moghbelinejad","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research, Institute for Prevention of Non\u2010Communicable Diseases Qazvin University of Medical Sciences Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112848"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2025.02.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248723"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02108-4"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.12.005"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.21.2492"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S144619"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa201"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01433-6"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.12.022"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2024.101537"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2017043"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i3.412"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107466"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr393"},{"issue":"9","key":"e_1_2_13_18_1","first-page":"6110","article-title":"Loss of HER2 and Disease Prognosis After Neoadjuvant Treatment of HER2+ Breast Cancer","volume":"11","author":"Branco F. P.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-022-00468-0"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0627"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2016.59.9.355"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4864-1"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09361-2"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-414"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.878471"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2014.0141"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1240098"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv379"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0806"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1616-x"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02309"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.07.016"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181c104c0"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429258589"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-04898-2_161"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"issue":"8","key":"e_1_2_13_37_1","first-page":"1564","article-title":"Age at Diagnosis of Breast Cancer in Iran: A Systematic Review and Meta\u2010Analysis","volume":"50","author":"Alizadeh M.","year":"2021","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.11.6905"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.12.5081"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.5152\/ejbh.2019.4890"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/381574"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2016.005397"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-14-113"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-302"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33846"},{"key":"e_1_2_13_46_1","first-page":"oyae283","article-title":"Breast Cancer Incidence and Mortality, by Age, Stage and Molecular Subtypes, by Race\/Ethnicity in Canada","author":"Wilkinson A. N.","year":"2024","journal-title":"Oncologist"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.23.00233"},{"issue":"5","key":"e_1_2_13_48_1","first-page":"444","article-title":"Menarche Age in Iran: A Meta\u2010Analysis","volume":"19","author":"Bahrami N.","year":"2014","journal-title":"Iranian Journal of Nursing and Midwifery Research"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2018.05.002"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-024-01839-0"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70425-4"},{"issue":"4","key":"e_1_2_13_52_1","first-page":"26","article-title":"A Systematic Review and Meta\u2010Analysis on the Average Age of Menopause Among Iranian Women","volume":"8","author":"Naz M. S. G.","year":"2018","journal-title":"Journal of Evidence\u2010Based Care"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijcm.5921"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09454-0"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.02.012"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.12368"},{"issue":"5","key":"e_1_2_13_57_1","first-page":"365","article-title":"Breastfeeding Experience and Breast Cancer Risk Among Postmenopausal Women","volume":"7","author":"Enger S. M.","year":"1998","journal-title":"Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630242.2015.1050547"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9820"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154819"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3462"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29070378"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2481021"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-12-16"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v6.i3.231"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.303"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.18160"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2016.0066"},{"issue":"3","key":"e_1_2_13_69_1","first-page":"243","article-title":"Epidemiology and Histopathology of Breast Cancer in Iran Versus Other Middle Eastern Countries. Middle East","volume":"9","author":"Nafissi N.","year":"2018","journal-title":"Journal of Cancer"},{"issue":"4","key":"e_1_2_13_70_1","first-page":"870","article-title":"Survival Rate of Breast Cancer and Related Factors in Iran: A 27\u2010Year Follow\u2010Up","volume":"54","author":"Mohammad Esmaeil A.","year":"2025","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1514"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq526"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.1558.13.10"},{"issue":"8","key":"e_1_2_13_74_1","first-page":"3911","article-title":"Survival of Triple Negative Versus Triple Positive Breast Cancers Comparison and Contrast","volume":"17","author":"Negi P.","year":"2016","journal-title":"Asian Pacific Journal of Cancer Prevention: APJCP"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12621-y"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9816"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85899-8"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:55:59Z","timestamp":1788342959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/hsr2.72150"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72150","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72150"}}