{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:18Z","timestamp":1787250318483,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Limited evidence suggests autoimmune thyroiditis (AT) could represent a risk factor for cervical artery dissection (CeAD). We tested the hypothesis of a positive association between AT and CeAD within 3 years following diagnosis compared to matched euthyroid controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched a de\u2010identified United States' data resource (TriNetX LLC) for adults age \u2265\u200918 with newly\u2010diagnosed AT, and euthyroid controls, from 2014 to 2024. Propensity matching controlled for variables associated with CeAD. Our primary outcome was the risk ratio (RR) for CeAD within 3 years' follow\u2010up. Secondary outcomes explored the cumulative incidence of CeAD and RRs for vertebral and carotid artery dissection and stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, there were 143,831 patients per cohort (80% female). Comparing the AT cohort to matched euthyroid controls, the incidence and risk of CeAD was significantly greater [95% CI] (0.040% vs. 0.025%; RR\u2009=\u20091.58 [1.04, 2.40];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029). Secondary outcomes included a non\u2010significant increase in incidence and risk of vertebral artery dissection (0.022% vs. 0.017%; RR\u2009=\u20091.28 [0.76, 2.16];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.354), and significant increase in incidence and risk of carotid artery dissection (0.019% vs. 0.008%; RR\u2009=\u20092.33 [1.19, 4.59];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and stroke (2.1% vs. 1.3%; RR\u2009=\u20091.67 [1.58, 1.77];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cumulative incidence of CeAD in patients with AT highlighted a time\u2010dependent increase relative to euthyroid controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present findings suggest that AT is a risk factor for CeAD. Additional research is needed to corroborate these findings and clarify factors that may mediate the AT\u2010CeAD association, such as medications, thyroid hormones, and antibody levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72161","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:46:48Z","timestamp":1774244808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Autoimmune Thyroiditis and Cervical Artery Dissection: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-1076","authenticated-orcid":false,"given":"Robert J.","family":"Trager","sequence":"first","affiliation":[{"name":"Connor Whole Health University Hospitals Cleveland Medical Center Cleveland Ohio USA"},{"name":"Department of Family Medicine and Community Health Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"Department of Biostatistics and Bioinformatics Clinical Research Training Program Duke University School of Medicine Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2483-984X","authenticated-orcid":false,"given":"Pratheek S.","family":"Makineni","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5992-8019","authenticated-orcid":false,"given":"Debbie S.","family":"Wright","sequence":"additional","affiliation":[{"name":"Parker University Dallas Texas USA"},{"name":"Private practice, The Grove Health and Wellness Courtenay British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2022.02.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.043647"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.18"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvac172"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000377"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12147"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-020-00208-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.174"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.52512"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2018.06.031"},{"key":"e_1_2_12_12_1","first-page":"510","article-title":"Dissecting Aneurysm of the Aorta and Hypothyroidism","volume":"30","author":"Rosenmann E.","year":"1994","journal-title":"Israel Journal of Medical Sciences"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000236500.15976.f3"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.820039"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000056"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.07.027"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319861869"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-85655-2"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26717"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.18502\/cjn.v21i3.11112"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.87883"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107384"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25813"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.7.851"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000078309.56307.5C"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.042367"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105490"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12155132"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvac016"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.5603\/fm.2013.0056"},{"key":"e_1_2_12_31_1","unstructured":"R. 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