{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:06Z","timestamp":1787250306319,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tuberculosis (TB) remains a significant public health problem in Ghana, with high morbidity and mortality rates. Persons with TB are at risk of adverse cardiovascular disease with hyperlipidemia being a major risk factor. The standard treatment for pulmonary TB includes a combination of anti\u2010tuberculosis drugs such as Rifampicin, Isoniazid, pyrazinamide, and ethambutol which have been associated with changes in lipid profile that could increase the risk of cardiovascular disease. Despite the existence of the links between cholesterol and TB, it is not clear to what extent the treatment of the disease affects lipid indicators in patients with TB, particularly in Ghana. This study, therefore, sought to investigate any differences in the concentration of lipid profile in Pulmonary Tuberculosis patients in Nsawam Adoagyiri Municipality vis\u2010sa\u2010vis pre\u2010 and post\u2010anti\u2010tuberculosis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional survey involving 210 participants was conducted in Nsawam\u2010Adoagyiri Municipal Hospital, in the Eastern Region of Ghana. Data were analyzed using STATA version 17. Categorical variables were presented as numbers (percentages). Continuous variables with normal distribution were expressed as mean\u2009\u00b1\u2009standard deviation. Inferential statistics were explored using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall dyslipidemia pre\u2010 and post\u2010tuberculosis treatment are 69.0% (145\/210) and 77.6% (163\/210) respectively. The mean Total Cholesterol and LDL increased significantly after the patient had completed the anti\u2010tuberculosis treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, there were no significant difference in the mean triglycerides (TG) and HDL levels before and after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that dyslipidemia is quite prevalent among TB patients attending the Nsawam Government Hospital, which may have a negative effect on their health and general well\u2010being. There is a significant difference in the lipid profile results of the participants\u2019 overall before and after the TB therapy. Anti\u2010TB treatment needs to develop more advanced recommendations that take patients' lipid levels into account in order to improve the outcomes for TB patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72175","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:01:15Z","timestamp":1774335675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dyslipidemia in Pulmonary Tuberculosis Patients Attending Nsawam Adoagyiri Municipal Hospital: Pre\u2010 and Post\u2010Anti\u2010Tuberculosis Treatment"],"prefix":"10.1002","volume":"9","author":[{"given":"Prince","family":"Agyeman","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science KAAF University College Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nixon Ntiri","family":"Somuah","sequence":"additional","affiliation":[{"name":"Department of Microbiology Nsawam\u2010Adoagyiri Municipal Hospital Nsawam Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yussif","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science University for Development Studies Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3799-2317","authenticated-orcid":false,"given":"Felix Abekah","family":"Botchway","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science Accra Technical University Accra Ghana"},{"name":"Accreditation and Affiliation Department Accra Technical University Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2020.02.005"},{"key":"e_1_2_11_3_1","unstructured":"W. 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