{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:23Z","timestamp":1787250323405,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Home blood transfusion is thought to be a promising solution for reducing the burden of hospital visits for elderly patients with hematologic diseases such as myelodysplastic syndrome and leukemia. However, safety concerns and reliance on nonprofessional attendants currently limit its widespread adoption in Japan. We evaluated feasibility (completion of scheduled measurement points per transfusion day) and operational safety (frequency of alerts and proportion leading to clinical actions) of intermittent vital sign monitoring with real\u2010time remote alerts during home blood transfusions in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five patients receiving home transfusions via Akasaka Clinic between December 2022 and February 2023 participated in the study. A digital tablet\u2010based system was preconfigured to connect with Bluetooth\u2010enabled vital sign devices (blood pressure monitor, thermometer, and pulse oximeter). Before transfusion, baseline vital signs were measured by the visiting physician; attendants then measured vitals at 15 and 60\u2009min and at the end of transfusion. Data were automatically transmitted to physicians via the Heartline\u2122 system. If preset thresholds were exceeded, alerts were triggered, which prompted professional medical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the 30\u2010day trial period, red blood cell transfusions were performed 27 times (each consisting of 2 units), and platelet concentrate transfusions were performed 15 times (each consisting of 10 units). Measurement completion rates ranged from 38% to 94% (median 70% [IQR 53\u201388]). Alerts occurred on 12\/30 days and totaled 12 alert events, corresponding to 28.6 alerts per 100 transfusions. Four of 12 alert events (33.3%) led to clinical actions (medication administration or initiation of home oxygen). Notably, intermittent measurement effectively identified clinically significant changes. Attendants, including elderly cohabitants, were able to operate the system with minimal burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intermittent, attendant\u2010performed vital sign monitoring with real\u2010time alerts enabled timely clinical responses and was feasible, even among elderly caregivers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72199","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:15:11Z","timestamp":1774336511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remote Vital Monitoring During Home Blood Transfusions in Japan Using Attendant\u2010Performed Vitals: A Pilot Feasibility and Safety Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9286-6909","authenticated-orcid":false,"given":"Akinori","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University Hospital Wakayama Japan"},{"name":"Division of Medical Informatics Wakayama Medical University Hospital Wakayama Japan"},{"name":"Akasaka Clinic Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Mitani","sequence":"additional","affiliation":[{"name":"Akasaka Clinic Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Miura","sequence":"additional","affiliation":[{"name":"Akasaka Clinic Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Akasaka Clinic Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.46439\/hematol.4.024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3925\/jjtc.63.664"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13380"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18344"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14816"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.380"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/23.022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-18036-5"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:47:17Z","timestamp":1787248037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/hsr2.72199"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72199","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72199"}}