{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:23:59Z","timestamp":1783023839075,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Incidence of diabetes is increasing at a younger age, causing a significant economic burden, especially in developing countries. This study was conducted to find the sociodemographic distribution of diabetes in young adults, along with clinical, laboratory, and treatment strategies used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional observational study was conducted including all young patients (20\u201339 years) diagnosed with diabetes in a tertiary center of Nepal over 1 year duration. Patients with secondary diabetes, such as gestational diabetes, were excluded. Sociodemographic, clinical, relevant laboratory parameters, and treatment\u2010related data were collected and analyzed using SPSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were a total of 133 patients, with a mean age of 31.40\u2009\u00b1\u20095.4 years. 82% were symptomatic at diagnosis, with polyuria as the most common symptom. The mean duration of diabetes was 5.4\u2009\u00b1\u20090.4 years, and 24% of the patients were insulin dependent. Family history of diabetes was present in 46 (34.60%). A total of 69 (52%) patients had some sort of complications, with the majority showing neuropathies. 31 (23%) developed ketoacidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on this study, we discovered that the presence of ketoacidosis is associated with patients with diabetes in the lower age group, relatively lower BMI, and heralds the T1DM group on the basis of clinical profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72206","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:12:18Z","timestamp":1776316338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Profile of Diabetes Mellitus in Young Patients Admitted at BP Koirala Institute of Health Sciences: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Dinesh","family":"Upreti","sequence":"first","affiliation":[{"name":"Maharajgunj Medical Campus Tribhuvan University Institute of Medicine  Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-5232","authenticated-orcid":false,"given":"Subarna","family":"Giri","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus Tribhuvan University Institute of Medicine  Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smile","family":"Kharel","sequence":"additional","affiliation":[{"name":"Universal College of Medical Sciences  Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmi","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Lumbini Medical College  Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Maskey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine BP Koirala Institute of Health Sciences  Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5195\/jcycw.2015.82"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12177"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03107-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610187"},{"issue":"1","key":"e_1_2_12_6_1","first-page":"356","article-title":"Clinical and Immunological Profile of Newly Diagnosed Patients With Youth Onset Diabetes Mellitus","volume":"2","author":"Dhanwal D. K.","year":"2014","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1447.056"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-060750"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3402\/gha.v8.29088"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4701796"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/cd17-0119"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3402\/gha.v9.31704"},{"issue":"9","key":"e_1_2_12_13_1","first-page":"739","article-title":"Demographic and Clinical Characteristics of Diabetes Mellitus Among Youth in Kashmir, India","volume":"3","author":"Daga R. A.","year":"2015","journal-title":"International Journal of Pediatrics"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.17511\/ijmrr.2015.i3.060"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-3930.37035"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3126\/jpahs.v8i1.36865"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3126\/jgmcn.v16i2.56382"},{"issue":"6","key":"e_1_2_12_18_1","first-page":"27","article-title":"Clinical and Aetiological Profile of Early Onset Diabetes Mellitus: Data From a Tertiary Care Centre in the Indian Subcontinent","volume":"47","author":"Zargar A. H.","year":"2001","journal-title":"Journal of Postgraduate Medicine"},{"issue":"8","key":"e_1_2_12_19_1","first-page":"553","article-title":"Risk Factor Study of Ischemic Stroke in Young Adults in Southwest China","volume":"43","author":"Zhang Y. N.","year":"2012","journal-title":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.33546\/bnj.2753"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:51:33Z","timestamp":1783021893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/hsr2.72206"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72206","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72206"}}