{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:20:06Z","timestamp":1783023606113,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although combined first trimester screening is effective at detecting fetal chromosomal anomalies which are trisomy 21, 18 and 13, there is scarce data on its practice and practice in low\u2010income countries. This study presents data on clinical use of combined first trimester prenatal screening tests among pregnant women in a Sub\u2010Saharan setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study was conducted over 7 years between July 2016 and June 2023 at St. Paul's Hospital Millennium Medical College (Ethiopia). Risk assessment was done with Snibe 2000 software using maternal age, nuchal translucency, PAPP\u2010A, \u03b2\u2010hCG and other maternal characteristics. Statistical analysis was done using SPSS version 22. Fishers exact and Man Whitney U test were done as appropriate, and\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value less than 0.05 was used to present significance of the results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 141 patients were included in the final analysis. Overall high\u2010risk cases for aneuploidy based on the combined test was 24.8%. Screening positive for aneuploidy had an association with increased nuchal translucency [median (IQR)\u2009=\u20092.1 (1.7, 2.5) for screening negative vs 2.9 (2.4, 2.9) for screening positive test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.021] and low PAPP\u2010A values\u2009\u2264\u20090.05 MoM (1 (5%) for negative and 5 (56%) for positive,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of screening positive for high\u2010risk aneuploidy in this study was higher than in previous reports which may be due to the fact that the study population is primary high\u2010risk women. Nuchal translucency and low PAPP\u2010A values were associated with screening positive for aneuploidy. Combined first trimester screening is feasible and effective for detecting fetal chromosomal anomalies in low\u2010income settings. Laboratory capacity for performing serum analytes and genetic testing, and availability of nuchal translucency ultrasound services should acted up on for creating a wider access to such vital prenatal genetic screening and testing services.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72282","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T13:49:16Z","timestamp":1775396956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Use of Combined First\u2010Trimester Screening Test for Aneuploidy in A Low\u2010Income Setting: Retrospective Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Tesfaye","family":"Diress","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Paul's Hospital Millennium Medical College (SPHMMC) Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekitie","family":"Wondafrash","sequence":"additional","affiliation":[{"name":"St. Paul Institute for Reproductive Health and Rights Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-6712","authenticated-orcid":false,"given":"Wondimu","family":"Gudu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Paul's Hospital Millennium Medical College (SPHMMC) Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulfetah Abdulkadir","family":"Abdosh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Paul's Hospital Millennium Medical College (SPHMMC) Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-0804","authenticated-orcid":false,"given":"Abraham Fessehaye","family":"Sium","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Paul's Hospital Millennium Medical College (SPHMMC) Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-033770"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12598"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4139"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.29"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)31025-2"},{"key":"e_1_2_11_7_1","article-title":"Non\u2010Invasiveprenatal Testing for Chromosomal Abnormality Using Maternal PlasmaDNA","volume":"15","author":"Royal College of Obstetricians and Gynaecologists","year":"2014","journal-title":"Scientific Impact Paper No"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000423819.85283.f4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","unstructured":"F. 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G.Zhang. \u201cGenetic Counseling Around the Globe: Prenatal Screening Practices During the First Trimester.\u201d (2021)."},{"key":"e_1_2_11_19_1","first-page":"1","article-title":"Challenges and Controversies in Prenatal Genetic Screening in the South African Context","volume":"28","author":"Bhorat I.","year":"2018","journal-title":"Obstet Gynaecol Forum"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2023.v113i11.885"},{"issue":"2","key":"e_1_2_11_21_1","first-page":"19","article-title":"Screening for Chromosomal and Structural Fetal Anomalies: Guidelines for South African Private Practice","volume":"1","author":"Pistorius L.","year":"2023","journal-title":"African Journal of Obstetrics and Gynaecology"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357430"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.949"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.068"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.2019.0029"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001040"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00604.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000191301.63871.c6"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2021.05.021"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:42:42Z","timestamp":1783021362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/hsr2.72282"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72282","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72282"}}