{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:17:36Z","timestamp":1785849456361,"version":"3.56.0"},"reference-count":95,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Palmoplantar pustulosis (PPP) is a chronic, recurrent, inflammatory disease and assumed to be a subtype of psoriasis. Pustular psoriasis (PP) is a chronic inflammatory disease that is further subclassified into various entities with different presentations including generalized pustular psoriasis (GPP) and palmoplantar pustular psoriasis (PPPP). Given the central role of the JAK\u2013STAT pathway in cytokine signaling, this systematic review evaluated the effectiveness and safety of Janus kinase inhibitors (JAK\u2010I) in these PP subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidelines, a systematic search was conducted across PubMed\/Medline, Scopus, Web of Science, and Embase up to November 13, 2025. Eligible studies included assessing JAK\u2010I in PPP, GPP, or PPPP. Exclusion criteria were reviews, articles without full\u2010text, SAPHO syndrome, and animal\/in vitro studies. Risk of bias was assessed using the NHLBI quality assessment tool for clinical studies and Murad et al.'s checklist for case reports\/series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven studies were included (29 case reports, 4 case series, and 4 clinical studies), encompassing 157 patients (60.5% female; mean age 46.8 years). Treatments involved tofacitinib, upadacitinib, baricitinib, abrocitinib, and topical ruxolitinib. In PPP, pooled meta\u2010analysis demonstrated a PPPASI\u201050 response rate of 85.5% (95% CI, 71.3\u201393.3), with upadacitinib achieving 90.9% (95% CI, 81.7\u201395.7). Case reports and series showed 88.1% clearance or near\u2010clearance within a mean of 2.5 months. GPP patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) achieved rapid clearance or marked improvement within 2\u201312 weeks. Adverse events (18.7%) were generally mild, most commonly acneiform eruptions, headache, and transient liver enzyme elevations, with no severe events reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>JAK\u2010I demonstrate high response rates and rapid improvement with manageable safety profiles. However, the current evidence is limited by small sample sizes, short follow\u2010up durations, and reliance on case\u2010based data. They represent a promising therapeutic option and warrant further evaluation in larger controlled studies to establish long\u2010term efficacy and safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72301","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:44:02Z","timestamp":1775537042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Janus Kinase Inhibitors for Treatment of Palmoplantar Pustulosis, Generalized Pustular Psoriasis, and Palmoplantar Pustular Psoriasis: A Systematic Review of the Literature"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8586-2432","authenticated-orcid":false,"given":"Mahshid Sadat","family":"Ansari","sequence":"first","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2683-3750","authenticated-orcid":false,"given":"Sama","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4069-7289","authenticated-orcid":false,"given":"Elnaz","family":"Pourgholi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Bahramian","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Tootoonchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-6803","authenticated-orcid":false,"given":"Seyed Mohammad","family":"Vahabi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13846"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.03.003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754231211342"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.12703\/r\/10-62"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S400402"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03296.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15826"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2185775"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0191-7"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S240607"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09819.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae217"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155215"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2019.1648209"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9121746"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.31.1.100"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048922"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00438-4"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2020.12.003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead448"},{"key":"e_1_2_12_22_1","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page M. 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