{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:18:27Z","timestamp":1788344307003,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["30187"],"award-info":[{"award-number":["30187"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Crigler\u2010Najjar Syndrome (CNS) is a rare autosomal recessive disorder caused by uridine diphosphate glucuronosyltransferase (UGT1A1) deficiency, leading to unconjugated hyperbilirubinemia. Without treatment, patients are at high risk of kernicterus and irreversible neurological damage. Liver transplantation (LT) is the only curative option. This study aims to evaluate long\u2010term outcomes of LT in CNS patients over a 20\u2010year period in Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, we analyzed 69 patients with CNS who underwent LT between 2000 and 2023 at Namazi Hospital and Abu Ali Sina Transplant Center in Shiraz, Iran. Long\u2010term follow\u2010up data, graft function, patient survival, and pre\u2010 and post\u2010LT outcomes were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Posttransplantation, bilirubin metabolism and liver function normalized rapidly. Within the first year, the overall mortality rate was 14.5%, mainly due to graft failure and sepsis. Late mortality (2.9%) was predominantly linked to chronic rejection and infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LT remains a definitive curative option for patients with CNS. However, postoperative complications, particularly hematologic and renal dysfunction, remain significant concerns. These findings underscore the importance of ongoing monitoring and optimization of post\u2010LT care. Furthermore, the lack of consensus regarding ideal timing for LT highlights the need for future prospective studies to better inform clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72393","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:19:47Z","timestamp":1777357187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver Transplantation Outcomes in Crigler\u2010Najjar Syndrome in Iran: A Single\u2010Center Retrospective Cohort Study Over 20 Years"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3193-8379","authenticated-orcid":false,"given":"Sajad","family":"Teimoury","sequence":"first","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-2555","authenticated-orcid":false,"given":"Zahra","family":"Beyzaei","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Shamsaeefar","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center, Abu\u2010Ali\u2010Sina Hospital Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurosh","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center, Abu\u2010Ali\u2010Sina Hospital Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Nikeghbalian","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center, Abu\u2010Ali\u2010Sina Hospital Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed\u2010Ali","family":"Malekhosseini","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center, Abu\u2010Ali\u2010Sina Hospital Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Geramizadeh","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Pathology Medical School of Shiraz University, Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Crigler\u2010Najjar Syndrome","author":"Bhandari 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