{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:01:27Z","timestamp":1789984887798,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Gram\u2010positive infections in burn patients present significant treatment challenges. This study compared the efficacy and safety of linezolid vs. teicoplanin for managing such infections in a clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective study involving 77 burn patients with confirmed Gram\u2010positive infections at Shahid Motahari Hospital (2020\u20132022). Participants were allocated to: linezolid 600\u2009mg BID (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940), teicoplanin 400\u2009mg daily (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932), or combination therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). Primary endpoints were treatment duration and mortality; secondary endpoints included safety outcomes. Statistical analyses used SPSS v25 with two\u2010tailed tests (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Linezolid demonstrated superior outcomes compared to teicoplanin: treatment duration was significantly shorter (5.68\u2009\u00b1\u20092.88 vs. 10.53\u2009\u00b1\u20096.86 days; mean difference \u22124.85 [95% CI \u22127.12 to \u22122.58],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), mortality lower (5.0% vs. 40.6%; OR\u2009=\u20090.09 [0.02\u20130.42],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and time to clinical improvement faster (4.94\u2009\u00b1\u20092.21 vs. 9.88\u2009\u00b1\u20095.95 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Safety profiles were comparable (thrombocytopenia: 5.0% vs. 12.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.602).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Linezolid showed significantly better efficacy than teicoplanin for Gram\u2010positive burn infections, with reduced treatment duration and mortality while maintaining similar safety. Teicoplanin remains an alternative for specific cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72411","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T04:40:46Z","timestamp":1780288846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effectiveness of Linezolid and Teicoplanin for Managing Infections After Burn Injuries: A Retrospective Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-8879","authenticated-orcid":false,"given":"Abolfazl","family":"Zendehdel","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Ziaeian Hospital Tehran University of Medical Sciences Tehran 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