{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:19:15Z","timestamp":1788344355842,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Diabetes is a significant disease that affects individuals of all ages and may lead to the development of systemic and ocular complications, ultimately resulting in a poor quality of life (QoL). The use of health\u2010related quality of life (HRQoL) measures is important for identifying disparities and those at risk, thereby promoting early intervention. This study aimed to examine the HRQoL and associated factors in Ghanaian children and adolescents with type 1 diabetes mellitus (T1DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study involving children and adolescents with T1DM aged 5\u201319 years was conducted. Demographic and clinical data of participants were recorded. Participants completed the PedsQL Generic Scales questionnaires. SPSS Version 25.0 was used in analyzing the data. Logistic regression was used in analyzing risk factors associated with poor QoL.\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values &lt;\u20090.05 were considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 46 children and adolescents with T1DM were analyzed. A female preponderance of 35\/46 (76.1%) was observed. The overall mean HRQoL score for participants was 73.9\u2009\u00b1\u200918.7. Sex was the only risk factor associated with poor self\u2010reported HRQoL in children and adolescents with T1DM. Female children and adolescents with T1DM were 13 times more likely to have poor self\u2010reported HRQoL compared with their male counterparts (OR\u2009=\u200913.2; 95% CI\u2009=\u20091.9\u201391.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). There were no significant associations with age, duration of diabetes, glycemic control, number of hypoglycemic and diabetic ketoacidosis episodes, hypertension, or nephropathy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Self\u2010reported QoL of children and adolescents with T1DM was poor. Female children and adolescents with T1DM are more likely to have poor self\u2010reported QoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72435","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:56:42Z","timestamp":1777363002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Health\u2010Related Quality of Life in Ghanaian Children and Adolescents With Type 1 Diabetes Mellitus: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2268-9032","authenticated-orcid":false,"given":"Benjamin","family":"Abaidoo","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Department of Surgery University of Ghana Medical School, University of Ghana Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-1123","authenticated-orcid":false,"given":"Akye","family":"Essuman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Health &amp; Allied Sciences Ho Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Adobea","family":"Essuman","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Department of Surgery University of Ghana Medical School, University of Ghana Accra Ghana"},{"name":"Eye Department Korle Bu Teaching Hospital Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naa Naamuah","family":"Tagoe","sequence":"additional","affiliation":[{"name":"Eye Department Korle Bu Teaching Hospital Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-3703","authenticated-orcid":false,"given":"Josephine","family":"Akpalu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics University of Ghana Medical School, University of Ghana Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana Ama","family":"Barnes","sequence":"additional","affiliation":[{"name":"Santa Rosa Community Health, Vista Clinic Santa Rosa California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauretta Pinamang","family":"Owusu\u2010Asare","sequence":"additional","affiliation":[{"name":"Eye Department Korle Bu Teaching Hospital Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0179-4119","authenticated-orcid":false,"given":"Yaw Akye","family":"Essuman","sequence":"additional","affiliation":[{"name":"Korle Bu Teaching Hospital Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Mawusime","family":"Beyuo","sequence":"additional","affiliation":[{"name":"Eye Department Korle Bu Teaching Hospital Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Ofori\u2010Adjei","sequence":"additional","affiliation":[{"name":"Eye Department Korle Bu Teaching Hospital Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-5579","authenticated-orcid":false,"given":"George Awuku","family":"Asare","sequence":"additional","affiliation":[{"name":"Chemical Pathology Unit, Department of Medical Laboratory Sciences University of Ghana School of Biomedical and Allied Health Sciences Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-7984","authenticated-orcid":false,"given":"Winfried 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