{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:17Z","timestamp":1790927657416,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Breast cancer continues to impose a considerable burden on women's health worldwide and represents one of the primary causes of cancer\u2010related mortality. Despite extensive research, regional data on its distribution and associated determinants remain essential. The present study evaluated the frequency of breast cancer and explored potential related factors among middle\u2010aged women in Isfahan, Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional epidemiological survey was performed between March 2021 and March 2022 across four university\u2010affiliated health centers in Isfahan. Information regarding sociodemographic characteristics, lifestyle behaviors, and medical history was gathered using a structured data collection form. Descriptive statistics were applied to summarize the data. Group comparisons were conducted using independent\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests for continuous variables and chi\u2010square tests for categorical variables. A confidence level of 95% was considered for statistical inference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 1001 women included in the analysis, 92 cases of breast cancer were identified, whereas 909 participants had no diagnosis of the disease. Statistical analysis revealed significant relationships between breast cancer and alcohol use (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) as well as height greater than 175\u2009cm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). No meaningful associations were observed for the remaining evaluated variables (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study findings indicate a potential link between alcohol consumption, increased height, and breast cancer occurrence in middle\u2010aged women. Further large\u2010scale, multi\u2010center investigations are warranted to confirm these observations and to enhance understanding of modifiable and non\u2010modifiable risk factors that may inform preventive strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72498","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T03:25:27Z","timestamp":1786332327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Breast Cancer Risk Factors Analysis in Middle\u2010Aged Women: Evidence From a Cross\u2010Sectional Epidemiological Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-5345","authenticated-orcid":false,"given":"Hourieh","family":"Ansari","sequence":"first","affiliation":[{"name":"Family and Community Medicine Department, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Yadollahi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, School of Medicine Isfahan University of Medical Science Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Allahyari","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, School of Medicine Isfahan University of Medical Science Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6467-2971","authenticated-orcid":false,"given":"Ali","family":"Hajigholami","sequence":"additional","affiliation":[{"name":"Internal Medicine, Division of Hematology and Oncology, School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-33347-7.00009-9"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S176070"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.61838\/kman.pwj.4.2.19"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i3.465"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21319"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_13_9_1","first-page":"1076","volume-title":"Presse Medicale","author":"Sancho\u2010Garnier H.","year":"2019"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.08.010"},{"issue":"3","key":"e_1_2_13_11_1","first-page":"243","article-title":"Epidemiology and Histopathology of Breast Cancer in Iran Versus Other Middle Eastern Countries","volume":"9","author":"Nafissi N.","year":"2018","journal-title":"Middle East Journal of Cancer"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-019-1119-y"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8500910"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70425-4"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09913-6"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.15540\/nr.11.4.355"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00952-0"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174287"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-105132"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-9-201205010-00006"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr454"},{"issue":"3","key":"e_1_2_13_22_1","first-page":"7","article-title":"Association of Obesity and Central Obesity With Breast Cancer Risk in Pre\u2010And Postmenopausal Women","volume":"15","author":"Hajian K.","year":"2013","journal-title":"Journal of Babol University of Medical Sciences"},{"key":"e_1_2_13_23_1","volume-title":"A survey on risk factors of breast cancer in women over 35 years of age","author":"Motamed N.","year":"2004"},{"issue":"3","key":"e_1_2_13_24_1","first-page":"395","article-title":"Risk Factors of Breast Cancer in North of Iran: A Case\u2010Control in Mazandaran Province","volume":"8","author":"Naieni K. 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