{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:01:31Z","timestamp":1789984891148,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Trauma is a leading cause of disability and mortality worldwide, with outcomes influenced by inflammatory responses. This study evaluated the association between trauma severity scores\u2014Shock Index (SI) and Assessment of Blood Consumption (ABC) score\u2014and systemic cytokine levels (IL\u20106 and IL\u201010) to assess their potential role in predicting clinical outcomes in trauma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective observational study was conducted with 20 adult trauma patients admitted to a tertiary hospital in S\u00e3o Paulo, Brazil (August 2022\u2013December 2022). Blood samples were collected at admission (T0) and 48\u2009h later (T1). Serum IL\u20106 and IL\u201010 were measured by ELISA. Severity was classified using SI (heart rate\/systolic blood pressure; &gt;\u20091 indicates hypovolemic shock) and ABC score (\u2009\u2265\u20092 parameters suggest high transfusion risk). Statistical analysis used the Wilcoxon signed\u2010rank test (paired comparisons), Mann\u2013Whitney for variation, and Spearman's correlation with 95% bootstrap confidence intervals (two\u2010tailed\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were predominantly male (18\/20, 90%) with blunt trauma (12\/20, 60%). IL\u201010 levels decreased significantly from T0 to T1 (median [IQR]: 7.7 [\u22121.5 to 20.2] pg\/mL vs. \u22121.4 [\u22125.4 to 5.9] pg\/mL; median difference\u2009=\u2009\u22127.2\u2009pg\/mL, 95% CI \u221216.1 to \u22121.2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). IL\u20106 remained stable (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.65), resulting in an increased IL\u20106\/IL\u201010 ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). IL\u20106 at T0 correlated positively with ABC score (Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.50, 95% CI 0.08\u20130.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). IL\u201010 at T0 correlated positively with Shock Index (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.47, 95% CI 0.04\u20130.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Trauma severity scores (ABC and SI) were associated with dynamic cytokine changes, particularly declining IL\u201010, suggesting a shift toward a pro\u2010inflammatory state 48\u2009h post\u2010injury. These findings support the potential integration of cytokine profiling with clinical scores to improve trauma risk stratification and guide early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72570","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:29:16Z","timestamp":1781674156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Inflammatory Cytokines (IL\u20106 and IL\u201010) and Trauma Severity: Correlations With Shock Index and ABC Score in Trauma Patients\u2014A Prospective Observational Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Rodrigo Gon\u00e7alves","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Health Science Post\u2010Graduate Department University of Santo Amaro  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Tiemi","family":"Shio","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Department University of Santo Amaro  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luis Lacerda","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Department University of Santo Amaro  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1061-3789","authenticated-orcid":false,"given":"Ana Paula","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Department University of Santo Amaro  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Olivio","family":"Sabbion","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0247-4245","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Colombo\u2010Souza","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Department University of Santo Amaro  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/0100-69912017004007"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_14_4_1","unstructured":"World Health Organization \u201cHealth Topics. 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