{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:39Z","timestamp":1789380219540,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>This study investigated the association between adherence to the EAT\u2010Lancet diet\u2014a predominantly plant\u2010based, anti\u2010inflammatory dietary pattern\u2014and the severity of pemphigus vulgaris (PV), a rare autoimmune blistering disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study was conducted in an Iranian population with a high incidence of PV and included 138 newly diagnosed patients. Disease severity was assessed using the Pemphigus Disease Area Index (PDAI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The findings revealed a significant inverse association between adherence to the EAT\u2010Lancet diet and PV severity. After adjus[tment for potential confounders, including age, sex, BMI, corticosteroid use, and caloric and carbohydrate intake, higher adherence to the diet remained consistently associated with markedly lower odds of severe PV (OR: 0.10; 95% CI: 0.02\u20130.40;\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u2009=\u20090.001), suggesting that dietary patterns may influence disease activity and progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although this cross\u2010sectional study has several important limitations\u2014including the inability to establish temporality, potential reverse causation, and a small number of severe cases\u2014the observed association between higher adherence to the EAT\u2010Lancet diet and lower pemphigus vulgaris severity should be interpreted as hypothesis\u2010generating. These findings may justify further research in larger longitudinal cohorts or dietary intervention trials, but they do not provide sufficient evidence to support dietary modification as an adjunctive clinical strategy for PV management at this stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72599","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:18:07Z","timestamp":1783340287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Effect of the EAT\u2010Lancet Diet on Pemphigus Vulgaris Severity: Insights From a Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3423-2225","authenticated-orcid":false,"given":"Pariya","family":"Mostafazadeh","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8989-1083","authenticated-orcid":false,"given":"Sajjad","family":"Etesamnia","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9191-9172","authenticated-orcid":false,"given":"Anahita","family":"Najafi","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-670X","authenticated-orcid":false,"given":"Kamran","family":"Balighi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Cancer Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Daneshpazhooh","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Cancer Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-3670","authenticated-orcid":false,"given":"Soraiya","family":"Ebrahimpour\u2010Koujan","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530121"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1159351"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-017-0008-1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2611"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04092.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1790-8"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3368786"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45139-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(24)00305-X"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31788-4"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-20564-y"},{"key":"e_1_2_13_13_1","volume-title":"Diets for a Better Future: Rebooting and Reimagining Healthy and Sustainable Food Systems in the G20","author":"Loken B.","year":"2020"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2021.126555"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03090-3"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-022-01246-8"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.784018"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155401"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31236-X"},{"issue":"1","key":"e_1_2_13_21_1","first-page":"5599","article-title":"Adherence to the EAT\u2010Lancet Diet and Incident Depression and Anxiety. Nature","volume":"15","author":"Lu X.","year":"2024","journal-title":"Communications"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.073"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2017.00009"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319654"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab369"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:11:48Z","timestamp":1789377108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/hsr2.72599"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72599","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72599"}}