{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:33:25Z","timestamp":1791959605421,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015400","name":"Fonds Erasme","doi-asserted-by":"publisher","award":["Bourse Chlo\u00e9"],"award-info":[{"award-number":["Bourse Chlo\u00e9"]}],"id":[{"id":"10.13039\/100015400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sperm quality at cancer diagnosis is often compromised by the disease and any given gonadotoxic treatment will further diminish fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Here, we aim to analyze the cryopreserved sperm quality according to the cancer types as well as the fertility outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study included all cancer patients who cryopreserved sperm over 20 years at Erasme Hospital Brussels (from 1999 to 2019). First sperm samples from 111 hematologic, 104 testicular, 19 prostate, 28 gastrointestinal, and 16 neurological cancer patients were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oligozoo\u2010asthenozoospermia was observed in 30% of the samples, including 19.33% with severe oligozoospermia (&lt;5\u2009million\/ml). Our results showed a significant reduction in sperm concentration among testicular cancer (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). No significant differences in progressive motility, sperm volume, and number of frozen straws were observed. Significant correlations were found between sperm concentration and cancer type (<jats:italic>p<\/jats:italic>\u2009&lt;0.01) as well as patients' age (<jats:italic>p<\/jats:italic>\u2009&lt;0.01). Twenty\u2010eight cancer survivors returned for using their cryopreserved sperm (9.33%), fertilization rate was 60.5% and implantation rate was 29.6%. There was no correlation between sperm concentration and fertility outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results confirm the negative impact of cancer on sperm quality without affecting assisted reproductive technology (ART) success rate, which is utterly important as a male reproductive health perspective. All cancer patients should be counselled and offered fertility preservation options as a gold standard.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.726","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T10:53:46Z","timestamp":1658314426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of cancer on cryopreserved sperm quality and fertility: A cohort study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-4361","authenticated-orcid":false,"given":"David","family":"Pening","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fertility Clinic CUB\u2014Erasme Hospital Brussels Belgium"},{"name":"Research Laboratory on Human Reproduction Erasme Campus Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnie","family":"Constant","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fertility Clinic CUB\u2014Erasme Hospital Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Bruynbroeck","sequence":"additional","affiliation":[{"name":"Fertility Clinic, IVF Laboratory CUB\u2014Erasme Hospital Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Delbaere","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fertility Clinic CUB\u2014Erasme Hospital Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Demeestere","sequence":"additional","affiliation":[{"name":"Research Laboratory on Human Reproduction Erasme Campus Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0001"},{"key":"e_1_2_13_4_1","unstructured":"Belgian Cancer Registry.\u00a0Tableaux sur base annuelle\u2014Belgian Cancer Registry;\u00a02021."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30677-0"},{"key":"e_1_2_13_6_1","unstructured":"International Agency for Research on Cancer WHO.Cancer Today; 2021."},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.006"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12894"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-018-1333-0"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh671"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez026"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12451"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex267"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00068"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30582-9"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758834016665078"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2021-0011"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010116"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.06.021"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp048"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.018"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.5.972"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.180061"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.02.015"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2013.3"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12610-016-0031-x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14434"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.06.016"},{"key":"e_1_2_13_29_1","doi-asserted-by":"crossref","unstructured":"AboulmaouahibS MadkourA KaarouchI et al.Impact of alcohol and cigarette smoking consumption in male fertility potential: looks at lipid peroxidation enzymatic antioxidant activities and sperm DNA damage.Andrologia.2018;50(3). Published online November 21 2021.doi:10.1111\/and.12926","DOI":"10.1111\/and.12926"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12910"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.04.010"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.10.007"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.02.006"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.10.055"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:35:49Z","timestamp":1692635749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/hsr2.726"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.726","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e726"}}