{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:01:27Z","timestamp":1789984887766,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["75123"],"award-info":[{"award-number":["75123"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["43014190"],"award-info":[{"award-number":["43014190"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Aortic aneurysm (AA) is a potentially fatal aortic disorder, particularly when complicated by rupture. Using Global Burden of Disease 2021 estimates, this study reported worldwide changes in AA mortality, disability\u2010adjusted life years (DALYs), and modeled risk\u2010attributable burden from 1990 to 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reported Global Burden of Disease 2021 estimates and summarized findings using counts, percentages, and age\u2010standardized rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, the global age\u2010standardized death rate for AA was 1.9 per 100,000, representing a 26.7% decrease since 1990. The global age\u2010standardized DALY rate was 36.5 per 100,000, reflecting a 25.1% reduction. The highest national DALY rates per 100,000 were estimated in Armenia (192.8), Montenegro (178.9), and Nauru (114.5), while the lowest were in Saudi Arabia (5.1), Tajikistan (5.7), and Sri Lanka (6.7). The largest increases in age\u2010standardized DALY rates occurred in Georgia (357.4%), Uzbekistan (320.6%), and Sudan (209.4%), whereas the greatest decreases occurred in Australia (\u221270.6%), Bermuda (\u221266.6%), and Canada (\u221265.9%). For both sexes, DALY rates were highest in the 95+ years group, indicating concentration of fatal burden at advanced age. Smoking, high systolic blood pressure, and high body mass index were the leading modeled contributors to global AA DALYs, accounting for 37.3%, 17.1%, and 8.0%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report identified marked variation in AA burden, potentially related to differences in screening, diagnosis, treatment access, and broader health\u2010system capacity. The results support targeted prevention, risk\u2010factor control, and improved vascular care, especially in resource\u2010limited settings. Reducing smoking and high systolic blood pressure may help lessen the future AA burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72601","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:48:53Z","timestamp":1780559333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Global Burden of Aortic Aneurysm and Its Attributable Risk Factors, 1990\u20132021: Results from the Global Burden of Disease Study 2021"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-9072","authenticated-orcid":false,"given":"Saeid","family":"Safiri","sequence":"first","affiliation":[{"name":"Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Genetics and Bioengineering Yeditepe University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Amiri","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuljit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gold Coast University Hospital Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Aletaha","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J. 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