{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:02:18Z","timestamp":1789984938426,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      is a key pathogen responsible for various infections, such as urinary tract infections, gastroenteritis, and wound infections. The increasing occurrence of antimicrobial resistance, particularly in extended\u2010spectrum \u03b2\u2010lactamase (ESBL)\u2010producing strains, poses a significant global health threat. This study aimed to assess the prevalence of fosfomycin resistance genes in ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      isolates from Abadan, southwest Iran.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From December 2020 to June 2021, 90\n                      <jats:italic>E. coli<\/jats:italic>\n                      isolates were obtained from clinical labs and healthcare centers affiliated with Abadan University of Medical Sciences. Antimicrobial susceptibility and ESBL production were determined using the disk diffusion method, while polymerase chain reaction was employed to detect relevant resistance genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fosfomycin resistance was observed in 5.6% of\n                      <jats:italic>E. coli<\/jats:italic>\n                      isolates. ESBL production occurred in 31.1% of isolates, with over half (53.6%) carrying the\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>CTX\u2010M<\/jats:sub>\n                      gene. Among ESBL producers, the\n                      <jats:italic>glpT<\/jats:italic>\n                      gene was the most prevalent (50%), followed by\n                      <jats:italic>fosA3<\/jats:italic>\n                      (10.7%) and\n                      <jats:italic>fosC2<\/jats:italic>\n                      (3.6%). Notably, the\n                      <jats:italic>fosA<\/jats:italic>\n                      gene was absent in all examined isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study reveals a rising prevalence of fosfomycin resistance among ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      isolates in Abadan, Iran. Ongoing surveillance of fosfomycin resistance is crucial for informing effective antimicrobial stewardship and treatment strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72612","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:46:39Z","timestamp":1780980399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of Fosfomycin Resistance Among ESBL\u2010Producing\n                    <i>Escherichia coli<\/i>\n                    in Abadan, Southwestern Iran"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-3827","authenticated-orcid":false,"given":"Nabi","family":"Jomehzadeh","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine Abadan University of Medical Sciences Abadan Iran"},{"name":"Department of Microbiology, Faculty of Medicine 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