{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:02:18Z","timestamp":1789984938350,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Hypertriglyceridemia\u2010induced acute pancreatitis (HTGAP) is a distinct clinical subtype of acute pancreatitis (AP), but comparative data remain limited. This study aimed to compare risk factors, disease severity, and clinical outcomes between patients with HTGAP and non\u2010HTGAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010center retrospective case\u2010control study was conducted using medical records of patients diagnosed with AP who were admitted to Imam Hospital (Ahvaz, Iran) between May 2020 and May 2025. Patients were categorized into HTGAP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009150) and non\u2010HTGAP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009150) groups. Demographic data, severity scores, clinical complications, and length of hospital stay were compared between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HTGAP was associated with significantly higher rates of complications, including acute respiratory distress syndrome, acute peripancreatic fluid collection, sepsis, acute necrotizing pancreatitis, pancreatic pseudocyst, walled\u2010off or infected pancreatic necrosis, and renal failure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). HTGAP patients were younger and had higher body mass index than non\u2010HTGAP patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). They also had significantly higher mean Ranson (3.18 vs. 2.53), 24\u2010h Acute Physiology, Chronic Health Evaluation II (APACHE II) (9.78 vs. 6.88), and modified computed tomography severity index (MCTSI) scores (7.08 vs. 4.54), as well as longer hospital stays (9.44 vs. 5.00 days), compared with non\u2010HTGAP patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No in\u2010hospital mortality occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HTGAP was associated with a more severe clinical profile and higher complication rates than non\u2010HTGAP, highlighting the need for early recognition and careful management. Interpretation of these findings is limited by the retrospective single\u2010center design and absence of multivariable adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72614","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:42:47Z","timestamp":1781073767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertriglyceridemia\u2011Induced Acute Pancreatitis Compared With Non\u2010Hypertriglyceridemia Acute Pancreatitis: A Retrospective Case\u2010Control Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Zahra","family":"Farhangiyan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Diabetes Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3319-6294","authenticated-orcid":false,"given":"Leila","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Diabetes Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Vaziri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Lak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Alimentary Tract Research Center, Clinical Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdos","family":"Zaman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Diabetes Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-1922","authenticated-orcid":false,"given":"Shooka","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30004-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20317"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74943-8"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"1","article-title":"Early Enteral Nutrition Compared to Other Methods in Acute Pancreatitis, a Literature Review","volume":"6","author":"Zare Shoki H.","year":"2017","journal-title":"Journal of Police Medicine"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.032"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.031"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0158-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0087-5"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3213"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.218"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040868"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.08.008"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283319a1d"},{"issue":"1","key":"e_1_2_12_16_1","first-page":"106","article-title":"Acute Pancreatitis Patient Registry to Examine Novel Therapies in Clinical Experience (APPRENTICE): An International, Multicenter Consortium for the Study of Acute Pancreatitis","volume":"30","author":"Papachristou G. 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