{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:01:10Z","timestamp":1789984870512,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis C virus (HCV) infection is one of the leading causes of liver\u2010related diseases such as cirrhosis and hepatocellular carcinoma. Despite ongoing efforts, no effective vaccine has been developed to date due to the virus's high mutation rate and extensive genetic variability. This study aimed to determine the prevalence of HCV infection among family members of HCV\u2010positive index cases, within related risk factors in them. Additionally, the study evaluated the therapeutic efficacy of the combination drug Sovodak (sofosbuvir\u2013daclatasvir) based on HCV genotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a descriptive cross\u2010sectional study conducted on the families of individuals with Hepatitis C (12 people) within the Guilan cohort population. Twenty family members of HCV\u2010positive individuals were enrolled. Data were collected using structured questionnaires that included socio\u2010demographic and clinical information. Blood samples were drawn from each participant, and sera were separated for serological analysis. HCV antibody\u2010positive samples were assessed by HCV\u2010RNA detection. Subsequently, positive samples underwent HCV genotyping. Then, HCV\u2010positive individuals were referred in Phase 3 clinical trial with ID: NCT03200184. for treatment and follow\u2010up. Treatment consisted of Sovodak (a combination of sofosbuvir 400\u2009mg and daclatasvir 60\u2009mg). The clinical and diagnostic effectiveness of the treatment was evaluated 12 weeks after therapy initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of the total cases, two were HCV antibody positive, and one of them was a 13\u2010year\u2010old girl who tested positive for HCV RNA by PCR. Her genotype was 1a, which matched her mother's genotype. This patient was successfully treated with Sovodak. The post\u2010treatment HCV RNA results were negative, indicating a sustained virologic response (SVR\u2009=\u200912).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Evidence of intrafamilial transmission was observed in this study, its frequency was extremely low and statistically negligible. Shared household items, although seemingly unlikely, such as toothpaste, may serve as a potential route of transmission within families, independent of direct interpersonal contact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72619","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:33:56Z","timestamp":1781069636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis C Virus Infection in the PERSIAN Guilan Cohort Study Population: Intrafamilial Transmission Incidence and Response to SOVODAK\u2010Based Therapy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-8879","authenticated-orcid":false,"given":"Farahnaz","family":"Joukar","sequence":"first","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Yeganeh","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-9548","authenticated-orcid":false,"given":"Narges","family":"Eslami","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-0787","authenticated-orcid":false,"given":"Fariborz","family":"Mansour\u2010Ghanaei","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30579-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18296-9"},{"key":"e_1_2_12_4_1","unstructured":"World Health Organization (WHO) \u201cHepatitis C \u201dhttps:\/\/cdn.who.int\/media\/docs\/default-source\/searo\/india\/health-topic-pdf\/factsheet-c-hepatitisday2016.pdf?sfvrsn=12404d40_2."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803233-6.00002-3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30264-X"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70079"},{"issue":"5","key":"e_1_2_12_8_1","first-page":"703","article-title":"Frequency and Genotype Distribution of Hepatitis C Virus Infection in Patients With Diabetes Type 2 in Ahvaz, Iran","volume":"13","author":"Makvandi M.","year":"2021","journal-title":"Iranian Journal of Microbiology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i10.1377"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102727"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2005.07.008"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2017-0007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.105311"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16071115"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16133-5"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13657"},{"key":"e_1_2_12_17_1","first-page":"27","article-title":"Prevalence OF HCV Among Household Members OF Hepatitis C Virus\u2010Infected Patients Attending Centre Universitaire De Sante Publique (CUSP) Health Center","volume":"12","author":"Nemeyimana P.","year":"2025","journal-title":"medRxiv"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/enj.enj_25_22"},{"issue":"1","key":"e_1_2_12_19_1","first-page":"39","article-title":"The PERSIAN Guilan Cohort Study (PGCS)","volume":"22","author":"Mansour\u2010Ghanaei F.","year":"2019","journal-title":"Archives of Iranian Medicine (AIM)"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-021-05474-2"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz628"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit648"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23522"},{"issue":"4","key":"e_1_2_12_25_1","first-page":"250","article-title":"Evaluation of Hepatitis C Virus Intrafamilial Transmission Among Families With One Index Case, a Pilot Study From Fars Province, Iran","volume":"9","author":"Lankarani K. 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