{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:02:52Z","timestamp":1789984972600,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Haploidentical hematopoietic stem cell transplantation (haplo\u2010HSCT) provides curative therapy for patients lacking HLA\u2010matched donors, yet optimal donor characteristics remain uncertain. This study assessed the effect of donor relationship, age, sex, and ABO compatibility on outcomes of haplo\u2010HSCT for acute leukemia under a uniform ATG\/post\u2010transplant cyclophosphamide (PTCy)\u2010based protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective single\u2010center cohort, 159 adults with acute myeloid or lymphoblastic leukemia received peripheral blood haplo\u2010HSCT following myeloablative busulfan\/cyclophosphamide plus ATG and PTCy (2015\u20132022). Overall survival (OS), disease\u2010free survival (DFS), GVHD\u2010free\/relapse\u2010free survival (GRFS), and relapse incidence were analyzed using Kaplan\u2013Meier and Fine\u2013Gray methods; predictors were evaluated by multivariable Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 159 patients, 96\/159 (60.4%) had AML and 63\/159 (39.6%) had ALL. Donors were siblings in 90\/159 (56.6%), parents in 48\/159 (30.2%), and offspring in 21\/159 (13.2%). Median recipient age was 27 years (range, 15\u201359), and median donor age was 31 years (range, 2\u201365). At 36 months, unadjusted outcomes varied across donor groups. In AML, OS was 52.7% (95% CI, 38.8\u201364.9) with sibling donors, 52.3% (95% CI, 29.4\u201371.0) with parent donors, and 32.1% (95% CI, 9.5\u201357.9) with offspring donors. In ALL, offspring donors were associated with numerically lower survival and higher relapse. In multivariable analysis, ALL (HR, 1.99; 95% CI, 1.25\u20133.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), advanced remission status (HR, 1.79; 95% CI, 1.16\u20132.77;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), and older recipient age (HR, 1.03 per year; 95% CI, 1.01\u20131.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independently associated with worse OS. Donor's age, sex, relationship, and ABO compatibility were not independently associated with major outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single\u2010center cohort of adults undergoing haploidentical HSCT with a uniform ATG\/PTCy\u2010based platform, donor relationship was associated with descriptive differences in unadjusted outcomes, but it was not an independent predictor in multivariable models. The inferior outcomes observed with offspring donors appeared to be influenced in part by older recipient age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Not applicable (retrospective study).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72631","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T13:41:17Z","timestamp":1781962877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Donor\u2010Related Factors Affecting Haploidentical HSCT Outcomes in Acute Leukemia: A Single\u2010Center Retrospective Cohort Study of a Modified Combination of Anti\u2010Thymocyte Globulin and Post\u2010Transplant Cyclophosphamide"],"prefix":"10.1002","volume":"9","author":[{"given":"Mahtab","family":"Mashayekhi","sequence":"first","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6272-2402","authenticated-orcid":false,"given":"Ghazaleh","family":"Kheiri","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-7154","authenticated-orcid":false,"given":"Fatemeh","family":"Salemi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Masoud","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies Research Center, Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0974-7158","authenticated-orcid":false,"given":"Hanieh","family":"Rouzbahani","sequence":"additional","affiliation":[{"name":"School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies Research Center, Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza Ostadali","family":"Dehaghi","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Azari","sequence":"additional","affiliation":[{"name":"Independent Researcher"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Janbabai","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-2819","authenticated-orcid":false,"given":"Maryam","family":"Barkhordar","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies Research Center, Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"e_1_2_17_2_1","volume-title":"Seminars in Hematology","author":"Chang Y.\u2010J.","year":"2019"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5726132"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563130"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-017-0062-8"},{"issue":"1","key":"e_1_2_17_6_1","first-page":"1","article-title":"Similar Outcomes Following 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