{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:02:39Z","timestamp":1789984959598,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic has significantly impacted global mortality, with marked variations according to demographic and temporal factors. This study aimed to analyze COVID\u201019 mortality trends and associated demographic factors in Chapec\u00f3, Southern Brazil, between 2020 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This population\u2010based retrospective observational study included all confirmed COVID\u201019 cases and related deaths recorded from March 2020 to March 2023. Data were obtained from the Municipal Epidemiological Surveillance Service. Demographic variables (age, sex, and year of occurrence) were analyzed. Mortality was evaluated using multivariable logistic regression models, incorporating variables selected based on epidemiological relevance. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Statistical significance was set at\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 84,814 COVID\u201019 cases and 861 deaths were recorded (case fatality rate: 1.02%). Mortality was higher among males (61.1%) and increased significantly with age, with a 10.2% higher odds of death per additional year of age. Compared with 2020, mortality risk was higher in 2021 (OR\u2009=\u20092.07; 95% CI: 1.72\u20132.50) and significantly lower in 2022 (OR\u2009=\u20090.15; 95% CI: 0.11\u20130.21). Peaks in case incidence during 2022 were not accompanied by proportional increases in mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COVID\u201019 mortality in Chapec\u00f3 was strongly associated with age and male sex. The substantial reduction in mortality after 2021 highlights the impact of vaccination and improved public health measures in mitigating pandemic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72644","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:26:02Z","timestamp":1781673962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["COVID\u201019 Mortality and Temporal Trends in a Mid\u2010Sized Southern Brazilian City (2020\u20132023): A Population\u2010Based Retrospective Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-8870","authenticated-orcid":false,"given":"Clodoaldo Ant\u00f4nio","family":"De S\u00e1","sequence":"first","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-5415","authenticated-orcid":false,"given":"Junir Antonio","family":"Lutinski","sequence":"additional","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-1725","authenticated-orcid":false,"given":"Sinval Adalberto","family":"Rodrigues\u2010Junior","sequence":"additional","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-9122","authenticated-orcid":false,"given":"Samuel Spiegelberg","family":"Zuge","sequence":"additional","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-3080","authenticated-orcid":false,"given":"Jeana Cristina","family":"Barretta","sequence":"additional","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6816-6203","authenticated-orcid":false,"given":"Felipe","family":"Corbellini","sequence":"additional","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-5686","authenticated-orcid":false,"given":"Ubiratan Alegransi","family":"Bones","sequence":"additional","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-528X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Ventura\u2010Silva","sequence":"additional","affiliation":[{"name":"Escola Superior de Sa\u00fade Norte da Cruz Vermelha Portuguesa Oliveira de Azem\u00e9is Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4234-4875","authenticated-orcid":false,"given":"Vanessa da Silva","family":"Corralo","sequence":"additional","affiliation":[{"name":"Universidade Comunit\u00e1ria de Regi\u00e3o de Chapec\u00f3 Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.2196\/26474"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.11606\/s1518-8787.2022056004907"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1242891"},{"issue":"1","key":"e_1_2_14_5_1","first-page":"S29","article-title":"General Aspects of the COVID\u201019 Pandemic","volume":"20","author":"Souza A. 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