{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:02:20Z","timestamp":1789984940272,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Breast cancer (BC) remains one of the leading causes of cancer\u2010related deaths among women worldwide. The\n                      <jats:italic>HER1<\/jats:italic>\n                      and\n                      <jats:italic>HER2<\/jats:italic>\n                      genes, both members of the epidermal growth factor receptor (\n                      <jats:italic>EGFR<\/jats:italic>\n                      ) family, have been extensively studied for their role in tumor development and progression. This study aims to investigate the association between BC risk and the\n                      <jats:italic>HER1<\/jats:italic>\n                      rs11543848 and\n                      <jats:italic>HER2<\/jats:italic>\n                      rs1136201 single nucleotide polymorphisms (SNPs) in the Bangladeshi population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This case\u2010control study comprised 112 BC patients from National Cancer Research Institute Hospital, Mohakhali, Dhaka, Bangladesh, and 124 age\u2010 and sex\u2010matched healthy controls (HCs) from nearby communities. Genotyping of\n                      <jats:italic>HER1<\/jats:italic>\n                      rs11543848 and\n                      <jats:italic>HER2<\/jats:italic>\n                      rs1136201 polymorphisms were carried out using the Tetra\u2010Primer Amplification Refractory Mutation System PCR (T\u2010ARMS PCR) method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>HER1<\/jats:italic>\n                      rs11543848 showed a strong association with BC risk under additive, dominant, and over\u2010dominant models (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), suggesting both GA and AA genotypes increase susceptibility. In contrast,\n                      <jats:italic>HER2<\/jats:italic>\n                      rs1136201 showed no significant association in most models, except for a modest effect under the over\u2010dominant model (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), indicating a potential heterozygote influence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings reveal a significant association between the\n                      <jats:italic>HER1<\/jats:italic>\n                      rs11543848 polymorphism and BC risk in the Bangladeshi population, while the\n                      <jats:italic>HER2<\/jats:italic>\n                      rs1136201 polymorphism shows limited association. This highlights the need for larger studies across diverse ethnic groups to validate these genetic factors influencing BC susceptibility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72672","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:01:45Z","timestamp":1781798505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Role of\n                    <i>HER1<\/i>\n                    and\n                    <i>HER2<\/i>\n                    Gene Variants in Breast Cancer Susceptibility: A Case\u2010Control Study in Bangladesh"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8778-9310","authenticated-orcid":false,"given":"Rana","family":"Tabassum","sequence":"first","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Al","family":"Abid","sequence":"additional","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh Shajia Islam","family":"Shithi","sequence":"additional","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usrat Rifat Binte","family":"Rafique","sequence":"additional","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamima","family":"Shultana","sequence":"additional","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Mohiuddin","sequence":"additional","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tanjum","sequence":"additional","affiliation":[{"name":"Research Lab, Rufaida BioMeds Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-3006","authenticated-orcid":false,"given":"Md. Aminul","family":"Haque","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.08.010"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.10528"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"96","article-title":"Knowledge, Attitude and Practice of Bangladeshi Women Towards Breast Cancer: A Cross Sectional Study","volume":"28","author":"Begum S. A.","year":"2019","journal-title":"Mymensingh Medical Journal: MMJ"},{"issue":"5","key":"e_1_2_12_5_1","first-page":"1568","article-title":"Breast Cancer in Low\u2010Middle Income Countries: Abnormality in Splicing and Lack of Targeted Treatment Options","volume":"10","author":"Francies F. 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