{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:02:20Z","timestamp":1789984940392,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>There is evidence of the beneficial effects of acupuncture in the treatment of polycystic ovary syndrome (PCOS). This study aimed to compare acupuncture with clomiphene in ovulation induction among infertile women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized clinical trial was conducted on infertile women with\u00a0PCOS who were referred to the gynecology clinic of Imam Reza Hospital and Milad Infertility Center, Mashhad, Iran, from December 2015 to July 2016. Patients were randomly assigned to two groups; the intervention group (38 patients) received true acupuncture plus placebo clomiphene, whereas the control group (39 patients) received clomiphene plus sham acupuncture. Patients were compared in terms of folliculare growth, evidence of ovulation, and side effects of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no statistically significant difference between the two groups in terms of demographic characteristics and PCOS\u00a0criteria. The ovulation rates were\u00a031.5% and 41.6% in the intervention and control groups respectively, indicating no statistically significant difference(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.36). Also, in terms of side effects, the statistical difference between the two groups was not significant, except for headache which was significantly more common in the intervention group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The rate of folliculargrowth was significantly higher in the control group during the first and third cycles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), whereas no significant difference was observed in the second cycle (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.93).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acupuncture can be as effective as clomiphene treatment in inducing ovulation in infertile women with PCOS. Moreover, considering the few side effects of acupuncture, its application can be considered a safe option.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      IRCT201512057265N3.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72673","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:23:36Z","timestamp":1781929416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acupuncture Versus Clomiphene for Ovulation Induction in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Clinical Trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Leili","family":"Hafizi","sequence":"first","affiliation":[{"name":"Supporting of the Family and the Youth of Population Research Core, Department of Obstetrics and Gynecology, Imam Reza Hospital, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Azizi","sequence":"additional","affiliation":[{"name":"Supporting of the Family and the Youth of Population Research Core, Department of Obstetrics and Gynecology, Imam Reza Hospital, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malihe","family":"Mahmoudinia","sequence":"additional","affiliation":[{"name":"Supporting of the Family and the Youth of Population Research Core, Department of Obstetrics and Gynecology, Imam Reza Hospital, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Jafari","sequence":"additional","affiliation":[{"name":"Supporting of the Family and the Youth of Population Research Core, Department of Obstetrics and Gynecology, Imam Reza Hospital, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza Bahrami","family":"Taghanaki","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, School of Persian and Complementary Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibollah","family":"Esmaili","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Health Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Golmohammadzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Mashhad University of Medical Sciences Mashhad 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