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Managing anxiety, depression, and stress is crucial in NAFLD care. Preliminary hypotheses suggest that\n                      <jats:italic>Portulaca oleracea<\/jats:italic>\n                      extract may improve mental health by modulating stress\u2010related hormones. The high flavonoid content and antioxidant characteristics may diminish inflammation and oxidative stress, which are principal factors contributing to both neuropsychological disorders and NAFLD\u2010related mental health issues. This study assessed changes in depression, anxiety, and stress levels using the DASS\u201021 scale in NAFLD patients after 8 weeks of supplementation with\n                      <jats:italic>Portulaca oleracea<\/jats:italic>\n                      extract.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a randomized clinical trial, 70 patients were divided into two groups: an intervention group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935) and a placebo group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935). The intervention group was administered 700\u2009mg of\n                      <jats:italic>P. oleracea<\/jats:italic>\n                      extract daily for 8 weeks, whereas the control group received a placebo. Each participant received a calorie\u2010restricted diet and directives for physical activity. Mental well\u2010being was assessed with the Depression, Anxiety, and Stress Scale (DASS\u201021). Dietary consumption was documented by 3\u2010day recalls both before and following the intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average age of the participants was 44.01\u2009\u00b1\u20098.6 years, with 34 (48.6%) being women. There were significant differences in weight and waist circumference in the intervention group as opposed to the group that received a placebo (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Depression and stress scores in the intervention group changed significantly compared to those in the study's placebo group, even after controlling for possible causes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002, 0.05, respectively). However, before and after controlling for variables including weight and physical activity, there were no appreciable variations in the two groups' anxiety scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1 and 0.12, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that an 8\u2010week supplementation with\n                      <jats:italic>Portulaca oleracea<\/jats:italic>\n                      can help alleviate depression and stress symptoms in patients with NAFLD.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Clinical trial registration code: IRCT20211116053073N1.\n                    <\/jats:p>\n                  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