{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:39Z","timestamp":1789380219528,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Knee osteoarthritis (KOA) is a major cause of pain, disability, and reduced quality of life worldwide. Exercise therapy is widely recommended as a first\u2010line non\u2010pharmacological treatment; however, evidence on a strengthening\u2010based home exercise program (SHEP) remains limited. This study aimed to investigate the effects of 8 weeks SHEP intervention on pain and function in KOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized controlled trial involved 247 KOA participants aged 45\u201370, who were randomly assigned to the experimental group receiving SHEP with lifestyle advice, or the control group receiving pain medication with lifestyle advice for 8 weeks. Primary outcomes included pain intensity measured using the Numeric Pain Rating Scale (NPRS), pressure pain threshold (PPT) assessed with an algometer, and functional ability measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Secondary outcomes included muscle strength, range of motion (ROM), Six\u2010Minute Walk Test (6MWT), and quality\u2010of\u2010life measures. Outcomes were assessed at baseline and after 8 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 8 weeks, the experimental group demonstrated significantly greater improvements than the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Pain intensity was reduced (mean difference [MD]\u2009=\u2009\u20131.95; 95% CI: \u20132.28 to \u20131.62), PPT increased (MD\u2009=\u20090.46; 95% CI: 0.32\u20130.60), and WOMAC total score improved (MD\u2009=\u2009\u201312.62; 95% CI: \u201314.37 to \u201310.86). Significant between\u2010group improvements were also observed in muscle strength, ROM, 6MWT, and quality\u2010of\u2010life scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No serious adverse events were reported throughout the trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eight weeks SHEP intervention was associated with significant improvements in pain, physical function, and quality of life in individuals with KOA. This intervention appeared to be feasible and was generally well tolerated by participants, supporting its potential as a sustainable rehabilitation strategy, particularly in resource\u2010limited healthcare settings.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ID: CTRI\/2025\/03\/081575.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72705","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:35:55Z","timestamp":1782714955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Strengthening\u2010Based Home Exercise Program on Pain and Function in Knee Osteoarthritis: Phase I Results of a Two\u2010Phase Randomized Controlled Trial"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9764-9174","authenticated-orcid":false,"given":"Kazi Md Azman","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation Jashore University of Science and Technology (JUST) Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannatul Ferdous","family":"Rikti","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation Jashore University of Science and Technology (JUST) Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Feroz","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation Jashore University of Science and Technology (JUST) Jashore Bangladesh"},{"name":"Department of Physiotherapy BRB Hospitals Limited Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Jahan","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation Jashore University of Science and Technology (JUST) Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-8079","authenticated-orcid":false,"given":"Ehsanur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation Jashore University of Science and Technology (JUST) Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2124-2087","authenticated-orcid":false,"given":"K. 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