{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:02:45Z","timestamp":1789380165613,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Hymenoptera venom hypersensitivity is a potentially life\u2010threatening condition that may affect up to 7.5% of adults worldwide and can result in systemic allergic reactions ranging from generalized cutaneous symptoms to severe anaphylaxis. Accurate diagnosis following a systemic sting reaction is essential to guide initiation of venom immunotherapy, a highly effective but resource\u2010intensive intervention. However, the diagnostic performance of commonly used tests, including venom skin testing, serum venom\u2010specific IgE, and component\u2010resolved diagnostics, varies across studies, contributing to uncertainty in clinical decision\u2010making. Prior evidence syntheses have largely relied on frequentist meta\u2010analytic approaches, which may be limited in handling sparse data and heterogeneity. This protocol describes a systematic review and Bayesian diagnostic test accuracy meta\u2010analysis to estimate the performance of tests for identifying IgE\u2010mediated Hymenoptera venom allergy in patients evaluated after systemic sting reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic searches will be conducted in MEDLINE, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials. Eligible studies will include diagnostic accuracy studies enrolling patients of any age evaluated after a systemic Hymenoptera sting reaction. Index tests will include venom skin testing, serum venom\u2010specific IgE (whole\u2010extract and component\u2010resolved diagnostics), and basophil activation testing. Study selection, data extraction, and risk of bias assessment using QUADAS\u20102 will be performed independently by two reviewers. Where sufficient comparable data are available, diagnostic accuracy will be synthesized using a Bayesian bivariate random\u2010effects meta\u2010analysis to jointly estimate sensitivity and specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The review will summarize study characteristics and construct study\u2010level 2\u00d72 diagnostic tables for each index test family. When feasible, pooled estimates of sensitivity and specificity with 95% credible intervals will be generated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review aims to provide clinically interpretable estimates of diagnostic test performance to support evidence\u2010based decision\u2010making and improve consistency in the evaluation of suspected Hymenoptera venom hypersensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72715","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:10:04Z","timestamp":1783339804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Accuracy of Tests for Hymenoptera Venom Hypersensitivity: A Systematic Review and Bayesian Meta\u2010Analysis 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