{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:02:37Z","timestamp":1789380157930,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302810"],"award-info":[{"award-number":["82302810"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404113"],"award-info":[{"award-number":["82404113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Hepatopancreatobiliary (HPB) surgeries, such as hepatic resection and pancreaticoduodenectomy, are associated with a high incidence of postoperative wound complications, particularly surgical site infections (SSIs). Negative pressure wound therapy (NPWT) has been proposed to reduce such complications, but its effectiveness in HPB surgery remains uncertain. This systematic review and meta\u2010analysis aimed to evaluate the association between NPWT and postoperative wound complications following HPB procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus through August 17, 2024 for randomized controlled trials (RCTs) and observational studies comparing NPWT with standard surgical dressing (SSD) after HPB surgery. Primary outcomes were overall, superficial, deep, and organ\u2010space SSIs. Secondary outcomes included seroma, hematoma, wound dehiscence, and hospital readmission. Risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using a random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven studies (7 RCTs, 4 observational;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091566) were included. Pooled analyses suggested that NPWT was associated with a lower risk of overall SSI compared with SSD (RR\u2009=\u20090.58, 95% CI\u2009=\u20090.45\u20130.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). When restricted to RCTs, the effect size was smaller and only approached statistical significance (RR\u2009=\u20090.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05). Superficial SSI (sSSI) rates were lower in the NPWT group, although this finding was not maintained in sensitivity analyses. No significant differences in deep or organ\u2010space infections, or other secondary outcomes. Subgroup analyses suggested a greater potential benefit in pancreatectomy cases (RR\u2009=\u20090.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). PICO devices were associated with reduced SSI risk, whereas PREVENA systems showed no statistically significant association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NPWT may reduce postoperative SSIs following HPB surgeries, particularly in patients undergoing pancreatectomy. However, the observed benefit was less robust in RCT\u2010only analyses, and evidence for liver surgery remains limited. Further high\u2010quality RCTs are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72749","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T03:23:04Z","timestamp":1783221784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Negative Pressure Wound Therapy for the Prevention of Wound Complications After Hepatopancreatobiliary Surgery: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Xiaofei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Peking University Shenzhen Hospital Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Peking University Shenzhen Hospital Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana C.","family":"Panayi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Peking University Shenzhen Hospital Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-7554","authenticated-orcid":false,"given":"Ziyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery Peking University Shenzhen Hospital, Shenzhen Peking University\u2014The Hong Kong University of Science and Technology Medical Center Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-3372","authenticated-orcid":false,"given":"Mengfan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking University Shenzhen Hospital Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13511"},{"issue":"8","key":"e_1_2_12_3_1","article-title":"Postoperative Infections in Hepatopancreatobiliary Malignancy: A Tertiary Care Center Experience","volume":"15","author":"Mahaddevappa B.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2017.10.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-012-0590-y"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.2021.25.1.97"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2021.08.021"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.2336"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-017-1681-0"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/715803"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-015-1279-x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.11124\/jbisrir-2015-1687"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0904"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30402-9"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102105"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.24764"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2023.24"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05116-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2022.06.020"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.38.8.6601"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2022.08.010"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_24_1","unstructured":"G. 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