{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:14Z","timestamp":1789380194496,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Androgenic alopecia (AGA) is a prevalent form of hair loss characterized by progressive miniaturization of hair follicles, significantly impacting patients\u2019 self\u2010confidence and quality of life. Current FDA\u2010approved treatments demonstrate limited to moderate efficacy. Microneedling combined with mesotherapy techniques has emerged as a promising drug delivery system for enhancing therapeutic outcomes in hair loss disorders. This retrospective interventional study aimed to evaluate the efficacy and safety of four distinct microneedling\u2010based mesotherapy protocols for the treatment of androgenic alopecia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010three patients with clinically confirmed AGA were allocated to four treatment groups. All groups received microneedling therapy combined with different mesotherapy formulations: Group I (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916) received 2\u2009mL hyaluronic acid (HA); Group II (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) received 1.5\u2009mL HA plus 0.5\u2009mL finasteride; Group III (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) received 1.5\u2009mL HA plus 0.5\u2009mL latanoprost; and Group IV (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) received 1\u2009mL HA plus 0.5\u2009mL finasteride and 0.5\u2009mL latanoprost. Patients underwent six treatment sessions at 3\u20134 week intervals. Standardized digital photographs were obtained at baseline, 3 months, and 6 months. Efficacy was assessed using physician satisfaction scores (treating and blinded evaluators) and patient satisfaction scores. Safety was monitored after each treatment session.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010nine women and 24 men completed the study. Women demonstrated significantly higher improvement rates (48%) compared to men (29%). Female pattern hair loss showed better response (45%) than male pattern AGA (37.5%). Participants under 30 years achieved higher improvement rates (47%) compared to those aged 30\u201349 years (42.9%). Group IV (combination therapy with finasteride and latanoprost) demonstrated the highest efficacy across both sexes and hair loss patterns. All treatment protocols were well\u2010tolerated with minimal adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of the current study support the use of combination mesotherapy protocols for enhanced therapeutic outcomes in AGA management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72760","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:22:24Z","timestamp":1782973344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Microneedling Combined With Mesotherapy for Androgenic Alopecia: A Retrospective Study Comparing Four Treatment Protocols"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-3460","authenticated-orcid":false,"given":"Elham","family":"Behrangi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hazrat Fatemeh Hospital, School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-8111","authenticated-orcid":false,"given":"Roya","family":"Zeinali","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hazrat Fatemeh Hospital, School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paria","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hazrat Fatemeh Hospital, School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Nosrati","sequence":"additional","affiliation":[{"name":"School of medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-4429","authenticated-orcid":false,"given":"Azadeh","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hazrat Fatemeh Hospital, School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S49337"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/cdr.cdr_29_21"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04289.x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb15179.x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197511000-00009"},{"issue":"5","key":"e_1_2_14_7_1","first-page":"202","article-title":"A Community Study of Male Androgenetic Alopecia in Bishan, Singapore","volume":"41","author":"Tang P. 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