{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:13Z","timestamp":1789380193797,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Donor\u2010related factors, including donor age, sex, and ABO compatibility, remain clinically relevant considerations in matched unrelated donor hematopoietic stem cell transplantation (MUD\u2010HSCT). However, their independent contribution to post\u2010transplant outcomes in contemporary practice is difficult to define, particularly in smaller institutional cohorts. We evaluated the association of selected donor characteristics with transplant outcomes in adult patients with acute leukemia undergoing MUD\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective single\u2010center cohort study included 85 consecutive patients with acute myeloid leukemia (AML;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945) or acute lymphoblastic leukemia (ALL;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) who underwent first MUD\u2010HSCT between 2015 and 2022. Overall survival (OS), disease\u2010free survival (DFS), and graft\u2010versus\u2010host disease\u2010free\/relapse\u2010free survival (GRFS) were analyzed using Kaplan\u2013Meier estimates and univariable Cox proportional\u2010hazards models. Relapse and non\u2010relapse mortality (NRM) were assessed using competing\u2010risk methods. Analyzes were restricted to univariable models because of limited event numbers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median recipient age was 27 years (range, 14\u201361), and the median donor age was 30 years (range, 14\u201373). Based on the Disease Risk Index recorded in the institutional database, 54 patients (63.5%) had high\u2010risk disease and 31 (36.5%) had standard\u2010risk disease. Donor age \u2265\u200930 years was not significantly associated with OS, DFS, GRFS, relapse, or NRM in either AML or ALL. ABO compatibility was also not significantly associated with these outcomes. In ALL, female donor sex was associated with inferior GRFS compared with male donor sex (HR, 3.21; 95% CI, 1.44\u20137.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), whereas no significant association with OS or DFS was observed. No significant donor sex\u2010related association was detected in AML.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single\u2010center cohort of patients undergoing MUD\u2010HSCT for acute leukemia, donor age and ABO compatibility were not statistically associated with major transplant outcomes. Female donor sex was associated with inferior GRFS in ALL, but this finding should be interpreted cautiously given the limited subgroup size, low event numbers, and absence of multivariable adjustment. Larger multicenter studies incorporating disease biology, MRD status, and transplant\u2010related covariates are needed to validate these observations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72775","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T03:27:59Z","timestamp":1783222079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Donor Age, Sex, and ABO Compatibility on Outcomes After Matched Unrelated Donor Hematopoietic Stem Cell Transplantation for Acute Leukemia: A Retrospective Single\u2010Center Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6272-2402","authenticated-orcid":false,"given":"Ghazaleh","family":"Kheiri","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab","family":"Mashayekhi","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-7154","authenticated-orcid":false,"given":"Fatemeh","family":"Salemi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza Ostadali","family":"Dehaghi","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Ghavamzadeh","sequence":"additional","affiliation":[{"name":"Cancer and Cell Therapy Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Cancer and Cell Therapy Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Azari","sequence":"additional","affiliation":[{"name":"Independent Researcher"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Babakhani","sequence":"additional","affiliation":[{"name":"Cancer and Cell Therapy Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-2819","authenticated-orcid":false,"given":"Maryam","family":"Barkhordar","sequence":"additional","affiliation":[{"name":"Research Institute for Oncology, Hematology and Cell Therapy Tehran University of Medical Sciences Tehran Iran"},{"name":"Cancer and Cell Therapy Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.05.035"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1339605"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25993"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.07.015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.01.073"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-663823"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.07.008"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-097386"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.01.084"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"51","article-title":"Selection of Suitable Alternative Donor in the Absence of Matched Sibling Donor: A Retrospective Single\u2010Center Study to Compare Between Haploidentical, 10\/10 and 9\/10 Unrelated Donor Transplantation","volume":"15","author":"Barkhordar M.","year":"2021","journal-title":"International Journal of Hematology\u2010Oncology and Stem Cell Research"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2022.106918"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.01.009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2017.11.008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.07.029"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.125294"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.147645"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2603"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-193409"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-210279"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12933"}],"updated-by":[{"DOI":"10.1002\/hsr2.72949","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000}}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72775","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:09:51Z","timestamp":1789376991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/hsr2.72775"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72775","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72775"}}