{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:36Z","timestamp":1789380216072,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is common to perform a splenectomy for patients with sickle cell disease (SCD); however, our understanding of its impact on long\u2010term clinical outcomes remains incomplete.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical outcomes of splenectomy in SCD patients and to assess perioperative physician practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cross\u2010sectional study that involved 245 adult Saudi patients with SCD, categorized into two groups: 40 patients who underwent splenectomy and 205 who did not. Data were gathered by structured interviews and electronic health records, including sociodemographic information, features of SCD, surgical procedures, and post\u2010splenectomy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The splenectomy group exhibited an increased frequency of acute chest syndrome (40% vs. 8.3%) and annual hospital admissions (8.7 vs. 3.35) due to pain crises before splenectomy. Following splenectomy, they demonstrated a notable decrease in hospital admissions and the need for blood transfusions (92.5% vs. 97.1%, 82.5% vs. 84.9%, respectively). Nevertheless, they exhibited a greater prevalence of stroke, venous thrombosis, and acute chest syndrome compared to the non\u2010splenectomy group (15% vs. 2.4%, 12.5% vs. 2.9%, and 45% vs. 8.3%). Patients aged \u2264\u200933 years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and those with comorbidities (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) demonstrated a significant response to splenectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Splenectomy in SCD patients may result in reduced hospital admissions and blood transfusion needs. Yet, it may elevate the risk of thromboembolic events and acute chest syndrome. Optimizing outcomes require careful patient selection and perioperative management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72778","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:09:46Z","timestamp":1783487386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Splenectomy Impact and Outcome Among Patients With Sickle Cell Disease: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-5550","authenticated-orcid":false,"given":"Mortadah","family":"Alsalman","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Medicine King Faisal University Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Bu\u2010Khamsin","sequence":"additional","affiliation":[{"name":"College of Medicine King Faisal University Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah","family":"AlSahaf","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Al Ahsa Health Cluster Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Al","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Al Ahsa Health Cluster Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema","family":"Alhelal","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Mouwasat Hospital  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Essa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menoufia University Shebin Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2716-5484","authenticated-orcid":false,"given":"Mohammed","family":"Alessa","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine King Faisal University Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-0363","authenticated-orcid":false,"given":"Somaia","family":"Shehab\u2010Eldeen","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine King Faisal University Al Ahsa Saudi Arabia"},{"name":"Tropical Medicine Department, Faculty of Medicine Menoufia University Shebin El\u2010kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Essa","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine King Faisal University Al Ahsa Saudi Arabia"},{"name":"Tropical Medicine Department, Faculty of Medicine Menoufia University Shebin El\u2010kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","article-title":"A Contemporary Review of the Management Strategies for Sickle Cell Disease Related Ischaemic and Stuttering Priapism","volume":"37","author":"Emmanuel A.","year":"2024","journal-title":"International Journal of Impotence Research"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vhri.2024.101038"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-209063"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S435861"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228399"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S393233"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2023000487"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2024000587"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.437"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2016.034"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.282556"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2022.02.010"},{"key":"e_1_2_12_14_1","first-page":"4793","article-title":"Splenomegaly in Adolescents and Adults With Sickle Cell Anemia in Tanzania Is Associated With Less Severe Disease","volume":"130","author":"Lubuva N. 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