{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:47Z","timestamp":1789380227146,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis D virus (HDV) remains underdiagnosed, and universal screening of HBsAg\u2010positive patients is recommended. We assessed changes in HDV diagnostic capacity across public hospitals in the Valencian Community, Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Repeated cross\u2010sectional surveys were conducted in 2024 and 2025. Analyses included the 19 hospitals participating in both years and evaluated anti\u2010HDV testing, HDV RNA detection, reflex testing, and clinician notification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anti\u2010HDV testing increased from 84.2% to 94.7%, HDV RNA testing from 68.4% to 84.2%, reflex testing from 43.8% to 77.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and direct clinician communication from 75.0% to 83.3%. Improvements were most marked in hospitals with fewer than 500 beds, where anti\u2010HDV testing rose from 78.6% to 92.9% and HDV RNA testing from 57.1% to 78.6%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HDV diagnostic capacity improved substantially, particularly in smaller hospitals. Further organizational measures are needed to achieve universal double\u2010reflex testing and timely communication of positive results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72802","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:59:09Z","timestamp":1784876349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improvement in the Microbiological Diagnosis of Hepatitis D on the Mediterranean Coast of Southeastern Spain: A Repeated Cross\u2010Sectional Survey"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1979-0949","authenticated-orcid":false,"given":"Maria Paz","family":"Ventero","sequence":"first","affiliation":[{"name":"Microbiology Service Alicante General University Hospital \u2010 Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"},{"name":"Faculty of Health Sciences International University of La Rioja (UNIR) Logro\u00f1o Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna","family":"Tyshkovska","sequence":"additional","affiliation":[{"name":"Microbiology Service Alicante General University Hospital \u2010 Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Carlos","family":"Castillo\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Microbiology Service Alicante General University Hospital \u2010 Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Reus","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Alicante General University Hospital \u2010 Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"de la Rica","sequence":"additional","affiliation":[{"name":"Microbiology Service Torrevieja University Hospital Torrevieja Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Orta","sequence":"additional","affiliation":[{"name":"Microbiology Service Francesc of Borja Hospital Gand\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conxa","family":"Serrat","sequence":"additional","affiliation":[{"name":"Microbiology Service La Pedrera Hospital Denia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gil","sequence":"additional","affiliation":[{"name":"Microbiology Service La Plana University Hospital Vila\u2010Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ortiz de la Tabla","sequence":"additional","affiliation":[{"name":"Microbiology Service Sant Joan D'Alacant Hospital San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-4110","authenticated-orcid":false,"given":"David","family":"Navarro","sequence":"additional","affiliation":[{"name":"Microbiology Service Valencia Clinical University Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Belda","sequence":"additional","affiliation":[{"name":"Microbiology Service Vega Baja Hospital Orihuela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olalla","family":"Martinez","sequence":"additional","affiliation":[{"name":"Microbiology Service La Ribera Hospital Alcira Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Coy","sequence":"additional","affiliation":[{"name":"Microbiology Service Marina Salud Denia Hospital Denia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Microbiology Service Sagunto Hospital Sagunto Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Magraner","sequence":"additional","affiliation":[{"name":"Microbiology Service Castellon Provincial Hospital Castellon Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepcion","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Microbiology Service Valencia General University Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maruan","family":"Shalabi","sequence":"additional","affiliation":[{"name":"Microbiology Service Marina Baixa Hospital Villajoyosa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Mar\u00eda","family":"Garcia\u2010Aguayo","sequence":"additional","affiliation":[{"name":"Microbiology Service Requena Hospital Requena Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Dolores","family":"Tirado\u2010Balaguer","sequence":"additional","affiliation":[{"name":"Microbiology Service Castellon General University Hospital Castell\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Microbiology Service Arnau of Vilanova Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Montserrat","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Microbiology Service Elche General University Hospital Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gasc\u00f3n","sequence":"additional","affiliation":[{"name":"Microbiology Service Elda General University Hospital Elda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Roig","sequence":"additional","affiliation":[{"name":"Microbiology Service Vinaroz Regional Hospital Vinaroz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Giner","sequence":"additional","affiliation":[{"name":"Microbiology Service La Fe University and Polytechnic Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Microbiology Service Dr. Peset University Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarna","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Microbiology Service Virgen de los Lirios Hospital Alcoi Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Llopis","sequence":"additional","affiliation":[{"name":"Microbiology Service Vinalopo Hospital Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Microbiology Service Alicante General University Hospital \u2010 Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1598784"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-07960-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2024.502222"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v14.i2.102673"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v17050667"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100547"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.16031"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15638"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-00101-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15776"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2025.502337"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:12:41Z","timestamp":1789377161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/hsr2.72802"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72802","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72802"}}