{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:51Z","timestamp":1789380231182,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, behavioral disturbances, and loss of functional independence. As the global prevalence of AD continues to rise, traditional episodic care models are increasingly inadequate for providing continuous and individualized support. Wearable electronic devices offer a potential alternative by enabling non\u2010invasive, real\u2010time monitoring in everyday settings. This systematic review synthesizes current evidence on the applications, reported outcomes, and implementation challenges of wearable and wearable\u2010adjacent technologies in AD care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted in September 2025 across five databases: PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, using keywords and MeSH terms related to wearable electronic devices, smart glasses, smartwatches, and Alzheimer's disease. The review protocol was prospectively registered in PROSPERO (CRD420251158703). Two independent reviewers screened records and extracted data in accordance with PRISMA 2020 guidelines. Methodological quality was assessed using a validated 10\u2010item appraisal tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1399 identified records, ten studies met the eligibility criteria. For structured synthesis, the included technologies were organized into four architectural categories: body area network\u2010based sensor systems, augmented reality smart glasses, hybrid wearable\u2013mobile platforms, and wearable\u2010adjacent assistive technologies. Across studies, the included technologies were applied to physiological monitoring, mobility and gait assessment, cognitive and spatial support, and caregiver communication. Findings suggest preliminary feasibility across these domains; however, small sample sizes, heterogeneous outcome measures, and predominantly early\u2010phase study designs limit the strength of available evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence suggests that wearable and wearable\u2010adjacent technologies may contribute to multiple aspects of AD care, particularly in home\u2010based settings. Translation into routine practice requires prospective, adequately powered studies with standardized outcome frameworks, alongside regulatory alignment and patient\u2013caregiver co\u2010design to address persistent usability barriers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72806","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:56:24Z","timestamp":1784094984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wearable Electronic Devices for Alzheimer's Disease Care: A Systematic Review of Applications, Benefits, and Challenges"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9868-6727","authenticated-orcid":false,"given":"Aynaz","family":"Esmailzadeh","sequence":"first","affiliation":[{"name":"Department of Health Information Technology Varastegan Institute for Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-9126","authenticated-orcid":false,"given":"Narges","family":"Norouzkhani","sequence":"additional","affiliation":[{"name":"Department of Health Information Technology, School of Management and Medical Informatics Tabriz University of Medical Sciences Tabriz East Azerbaijan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sezavar Dokhtfaroughi","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering Technical and Vocational University (TVU) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3947-2885","authenticated-orcid":false,"given":"Alireza","family":"Rasoulian","sequence":"additional","affiliation":[{"name":"Department of Health Information Technology Varastegan Institute for Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8096-2530","authenticated-orcid":false,"given":"Mohammad Reza","family":"Mazaheri Habibi","sequence":"additional","affiliation":[{"name":"Department of Health Information Technology Varastegan Institute for Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.03.012"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.02.001"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079378"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.006"},{"key":"e_1_2_15_6_1","unstructured":"Organization WH. 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