{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:03:25Z","timestamp":1789380205510,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pneumococcus are often found in the respiratory tract of healthy people, especially children, and are a common cause of infections such as otitis media, sinusitis, conjunctivitis and community\u2010acquired pneumonia. In other cases, the bacteria can cause more serious conditions known collectively as invasive pneumococcal disease (IPD), which include meningitis, bacteremia and osteomyelitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of the present study was to determine the burden and incidence of hospitalizations caused by S. pneumoniae in the pediatric population resident in Abruzzo region, Italy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study. All admissions performed during the period 2018\u20132023 were extracted from the hospital discharge records. Hospitalization rates were directly standardized for age and gender, accordingly to the population of Abruzzo region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The annual hospitalization rate for SP pneumonia during the study period showed a significant decrease between the years 2018\u20132021 with an APC of \u221214.6 (95% CI: \u221236.1\u20130.6), followed by a substantial increase across the period 2021\u20132023 with a significant APC of 74.2 (95% CI: 27.9\u2013127.3). For meningitis, an increasing trend was observed between 2018 and 2020, with an AAPC of 6.1 (95% CI: 1.6\u201310.9), followed by a decline in 2021 and 2022. Bacteremia was stable during the study period. Conclusions: This study shows that pneumococcal disease has a significant impact on the pediatric population and on the health care system. These findings highlight the importance of improving vaccination of newborns and monitoring the circulation of pneumococcal serotypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72807","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:34:31Z","timestamp":1784183671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Burden of Streptococcus Pneumoniae\u2010Related Admissions in Pediatric Population: A Retrospective Cohort Study Between Years 2018\u20132023 From a Southern Italian Region"],"prefix":"10.1002","volume":"9","author":[{"given":"Pamela","family":"Di Giovanni","sequence":"first","affiliation":[{"name":"Department of Medicine and Ageing Sciences \u201cG. d'Annunzio\u201d University of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-7611","authenticated-orcid":false,"given":"Giuseppe","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences \u201cG. d'Annunzio\u201d University of Chieti\u2010Pescara Chieti Italy"},{"name":"Unit of Epidemiology and Health Statistic Local Health Authority of Pescara Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Petrangelo","sequence":"additional","affiliation":[{"name":"School of Hygiene and Preventive Medicine \u201cG. d'Annunzio\u201d University of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Donatiello","sequence":"additional","affiliation":[{"name":"School of Hygiene and Preventive Medicine \u201cG. d'Annunzio\u201d University of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences \u201cG. d'Annunzio\u201d University of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Tognaccini","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cLa Sapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Trebbi","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cLa Sapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Aita","sequence":"additional","affiliation":[{"name":"Local Health Authority of Avezzano\u2010Sulmona\u2010L'Aquila L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases \u201cLa Sapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Staniscia","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences \u201cG. d'Annunzio\u201d University of Chieti\u2010Pescara Chieti Italy"},{"name":"Unit of Epidemiology and Health Statistic Local Health Authority of Pescara Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10091375"},{"key":"e_1_2_11_3_1","unstructured":"WHO. 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[Online] [Cited: Marzo 24 2025] https:\/\/demo.istat.it\/."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12010172"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15051160"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(21)00077-7"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases12010026"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10050871"},{"key":"e_1_2_11_21_1","unstructured":"Dipartimento Per Gli Affari Regionali E Le Autonomie. Servizio \u201cSanit\u00e0 Lavoro E Politiche Sociali \u201d Piano Nazionale Prevenzione Vaccinale PNPV 2023\u20132025. 20 Marzo 2023 https:\/\/storagehub.homnya.net\/cmsimage\/allegati\/allegato1743582691.pdf."},{"key":"e_1_2_11_22_1","unstructured":"Istituto Superiore di Sanit\u00e0. Copertura Vaccinale in Italia. EpiCentro \u2010 L'Epidemiologia Per La Sanit\u00e0 Pubblica. 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