{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T11:23:31Z","timestamp":1794309811050,"version":"4.9.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Congenital heart disease (CHD) is a significant cause of infant mortality. In Pakistan, inadequate screening in healthcare settings and under\u2010reporting of CHD cases contribute to high mortality and morbidity rates. This study aimed to determine the prevalence and case fatality rate of CHD over a decade among neonates and post\u2010neonatal infants in Buner, Khyber Pakhtunkhwa (KP), Pakistan. Clarifying the epidemiological profile of CHD in this region is vital for strengthening early detection in newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single\u2010center study was conducted at the District Headquarter Hospital, District Buner. Data related to various parameters were extracted from hospital records and presented as prevalence and case fatality rate (CFR). Time\u2010series analysis was performed to assess trends over the years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, a total of 733 cases of CHD were identified among 78,713 newborns. Of these cases, 415 (56.6%) were male infants, while 318 (43.4%) were female. The prevalence rate varied, with a peak in 2023 at 17.05 per 1000 and a trough in 2018 at 5.15 per 1000. Over the 11 years, the overall CFR was 36.7%, with the highest in 2021 at 68.1% and the lowest in both 2015 and 2018 at 27.7% each. The number of CHD cases increased significantly over time, rising from 47 (0.86%) in 2013 to 139 (1.7%) in 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The data indicate a consistent rise in CHD cases, along with an increasing case fatality rate and prevalence over the years in District Buner, Pakistan. This study underscores the need for improved screening protocols for CHD and the adoption of electronic health records to enable timely reporting of CHD cases among neonates and post\u2010neonatal infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72812","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:48:58Z","timestamp":1784616538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Case Fatality of Congenital Heart Disease in Pakistani Infants: A 11\u2010Year Retrospective Time\u2010Series Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-2938","authenticated-orcid":false,"given":"Ijaz ul","family":"Haq","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory Of Neonatal Diseases, Children's Hospital of Fudan University at Xiamen, Xiamen Children's Hospital Xiamen Fujian China"},{"name":"Nursing Department Children's Hospital of Fudan University Shanghai China"},{"name":"Department of Public Health &amp; Nutrition The University of Haripur Haripur Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Imran","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Public Health &amp; Nutrition The University of Haripur Haripur Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Pediatrics Department Lady Reading Hospital, MTI Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehwish","family":"Fayaz","sequence":"additional","affiliation":[{"name":"Department of Public Health &amp; Nutrition The University of Haripur Haripur Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Public Health &amp; Nutrition The University of Haripur Haripur Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Numan","family":"Khan","sequence":"additional","affiliation":[{"name":"Saidu Teaching Hospital Saidu Sharif Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Bin Afsar","family":"Jan","sequence":"additional","affiliation":[{"name":"Paediatrics &amp; Neonates Department Hayatabad Medical Complex Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-5839","authenticated-orcid":false,"given":"Guo\u2010ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory Of Neonatal Diseases, Children's Hospital of Fudan University at Xiamen, Xiamen Children's Hospital Xiamen Fujian China"},{"name":"Shanghai Key Laboratory of Birth Defects Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-7475","authenticated-orcid":false,"given":"Hu","family":"Xiaojing","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory Of Neonatal Diseases, Children's Hospital of Fudan University at Xiamen, Xiamen Children's Hospital Xiamen Fujian China"},{"name":"Nursing Department Children's Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2020.06.013"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X20926041"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1261130"},{"issue":"9","key":"e_1_2_14_5_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.70413\/ejar-v03-i09-s4249","article-title":"Perinatal Cardiology: Pregnancy and Congenital Heart Defects","volume":"3","author":"Shopulotova Z.","year":"2023","journal-title":"Eurasian Journal of Academic Research"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60010094"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2022.04.004"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.150.suppl_1.4146287"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/pm-23-45"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60107-X"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3211"},{"issue":"1","key":"e_1_2_14_12_1","article-title":"Prevalence and Pattern of Congenital Heart Disease Among Children in Khartoum State, Sudan: A Reflection of the Current Cardiac Profile","volume":"14","author":"Abdelrahman O.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-06193-1"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-04678-z"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.29309\/TPMJ\/2020.27.11.5866"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.47144\/phj.v55i1.2126"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101249"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30402-X"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.154"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.3022"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.29309\/TPMJ\/2023.30.10.7593"},{"key":"e_1_2_14_22_1","volume-title":"Encyclopedia Britannica","author":"Harrington R. 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