{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:02Z","timestamp":1790927642571,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Septic arthritis (SA) is considered the most harmful etiology in patients presenting with an acutely painful swollen knee. This study aimed to estimate the incidence, mortality rate, and cause of death among patients diagnosed with SA and compare it to non\u2010infectious causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a population\u2010based observational cohort study in Sk\u00e5ne, southern Sweden, with a population of 1.4 million people. We included adults in the years 2020 and 2021 with cultures obtained at the emergency department from a native knee, where SA was considered a differential diagnosis based on medical chart review. Data on demographics, comorbidities, microbiological etiology, mortality, and treatment were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 709 knee joint cultures, 60 (8%) cultures were considered SA. The median age of included patients was 71 years (range 19\u201397) and 67% were men. The incidence of SA was 2.7 cases per 100,000 person\u2010years. Gout and pyrophosphate arthritis were more prevalent than SA (5.7\/100,000 person\u2010years and 6.1\/100,000 person\u2010years, respectively. The 90\u2010day all\u2010cause mortality rate for SA was 8% (4\/51), compared to mortality rates of 4% (5\/126) for gout arthritis and 4% (5\/139) for pyrophosphate arthritis, respectively. Possibly one death within 90\u2010days was considered directly associated to SA (2%). No deaths were considered preventable due to inadequate antimicrobial therapy or management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed a low incidence of native knee SA, with gout and pyrophosphate arthritis occurring twice as frequently. In our cohort, the infection\u2010related mortality from SA was low and considered non\u2010preventable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72845","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T05:58:11Z","timestamp":1786082291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Septic Arthritis and Its Mimics: Assessing the Incidence, Mortality Rate, Cause\u2010of Death and Preventability in a Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5030-9119","authenticated-orcid":false,"given":"Amelia","family":"Johansson","sequence":"first","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine Lund University Lund Sweden"},{"name":"Department of Internal Medicine Helsingborg Hospital Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Bornai","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Tverring","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine Lund University Lund Sweden"},{"name":"Department of Infectious Diseases Helsingborg Hospital Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Ljungquist","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine Lund University Lund Sweden"},{"name":"Department of Infectious Diseases Helsingborg Hospital Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291407"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.16.5.355"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.12998"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61595-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2011.01121.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.077131"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1540-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.4.214"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182577"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23270"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7571"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-11306-6"},{"key":"e_1_2_11_14_1","unstructured":"MDCalc. Charlson Comorbidity Index (CCI) [Internet]. \u201cMDCalc \u201d 2022 [cited 2022 Dec 7] https:\/\/www.mdcalc.com\/calc\/3917\/charlson-comorbidity-index-cci."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.3.198"},{"issue":"891","key":"e_1_2_11_17_1","article-title":"Increased Incidence and Clinical Features of Septic Arthritis in Patients Aged 80 Years and Above: A Comparative Analysis With Younger Cohorts","volume":"13","author":"Alexandersson H.","year":"2024","journal-title":"Pathogens"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0441-1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-023-01106-9"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12195"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.72845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.72845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:12:03Z","timestamp":1790925123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.72845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/hsr2.72845"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.72845","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72845"}}