{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:55:47Z","timestamp":1791186947609,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005716","name":"Babol University of Medical Sciences","doi-asserted-by":"publisher","award":["724134811"],"award-info":[{"award-number":["724134811"]}],"id":[{"id":"10.13039\/501100005716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Miscarriage can lead to various psychological consequences such as grief, anxiety, depression, and psychological distress. Although women who experience a miscarriage may not have formed a bond with their unborn child, the intensity of grief following an abortion does not significantly differ from the loss of other first\u2010degree relatives. The present study will be conducted to compare therapist\u2010guided versus self\u2010guided internet\u2010based stress inoculation therapy (ISIT) on psychological distress symptoms in women after miscarriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study will be a randomized clinical trial with two parallel groups, conducted on 100 women with a history of miscarriage who are referred to prenatal clinics of educational hospitals affiliated with Babol University of Medical Sciences. Participants will be randomly assigned to two intervention groups. The first group will receive therapist\u2010guided intervention (50 participants), consisting of 6 sessions of ISIT along with 20\u201325\u2009min of weekly online counseling. The second group will receive a self\u2010guided intervention (50 participants), consisting of only 6 sessions of ISIT without therapist guidance. The content of the SIT sessions includes techniques such as relaxation, cognitive restructuring, conceptualization, problem\u2010solving, exercises, cognitive\u2010behavioral methods, and stress coping. Data will be collected using demographic\u2010reproductive characteristics questionnaires, brief symptom inventory\u201018 (BSI\u201018), and Perinatal Grief Scale at three time intervals: before the intervention, immediately after the intervention, and 3 months after the intervention. Data analysis will be performed using independent\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, Chi\u2010square tests, and repeated measures analysis of variance with SPSS software version 23.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>It is expected that the study will yield anticipated outcomes in reducing psychological distress symptoms among women following a spontaneous abortion. It is also anticipated that counseling based on this model will reduce perinatal grief during follow\u2010ups conducted immediately post\u2010intervention and 3 months after the intervention concludes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The positive results of ISIT counseling on psychological distress symptoms and reducing perinatal grief during follow\u2010ups conducted immediately post\u2010intervention and 3 months after the intervention suggest that it will be useful for managing the complications of spontaneous abortion.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      This trial is prospectively registered on August 25, 2025, at the Iranian Registry of Clinical Trials (IRCT20230130057274N6).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72846","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:39:12Z","timestamp":1787737152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Therapist\u2010Guided Versus Self\u2010Guided Internet\u2010Based Stress Inoculation Therapy (ISIT) on Psychological Distress Symptoms in Women After Miscarriage in Iran: A Study Protocol of a Randomized Clinical Trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Nazanin","family":"Karimihamzekolaee","sequence":"first","affiliation":[{"name":"Student Committee of Research Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-8141","authenticated-orcid":false,"given":"Hajar","family":"Adib\u2010Rad","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research 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