{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:04Z","timestamp":1790927644869,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The combined prognostic value of metaflammation and vascular aging markers in cardiovascular\u2010kidney\u2010metabolic (CKM) syndrome is unclear. This study aimed to assess the independent and joint associations of the C\u2010reactive protein\u2010triglyceride glucose index (CTI) and estimated pulse wave velocity (ePWV) with all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 7183 participants from the CHARLS 2011 survey (original cohort) and 9594 from 2015 (temporal sensitivity analysis cohort). Multivariable Cox models and restricted cubic splines were used. Joint effects were analyzed by median\u2010based groups, and mediation was tested using the KHB method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow\u2010up, 906 deaths occurred in the original cohort. Each 1\u2010unit increase in CTI was associated with a 56% higher mortality risk (HR\u2009=\u20091.56, 95% CI: 1.37\u20131.77), and each 1\u2009m\/s increase in ePWV with an 11% higher risk (HR\u2009=\u20091.11, 95% CI: 1.05\u20131.18). The high CTI\/high ePWV group had the highest risk (HR\u2009=\u20091.73, 95% CI: 1.31\u20132.29). ePWV mediated 6.48% of the CTI\u2010mortality association, while CTI mediated 2.62% of the ePWV\u2010mortality association. These findings were confirmed in the temporal sensitivity analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CTI and ePWV independently and jointly associate with increased all\u2010cause mortality. The observed bidirectional mediation suggests potentially interconnected pathways that warrant further investigation. Integrating these accessible biomarkers could improve risk stratification in CKM syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72870","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:16:02Z","timestamp":1785273362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of C\u2010Reactive Protein\u2010Triglyceride Glucose Index and Estimated Pulse Wave Velocity With All\u2010Cause Mortality: A Nationwide Prospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1768-7947","authenticated-orcid":false,"given":"Huixiao","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of General Practice, Shanghai East Hospital Tongji University School of Medicine Shanghai China"},{"name":"Department of Geriatrics, Shanghai East Hospital Tongji University School of Medicine Shanghai 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